Myofibroblast transdifferentiation: The dark force in ocular wound healing and fibrosis
Wound healing is one of the most complex biological processes to occur in life. Repair of
tissue following injury involves dynamic interactions between multiple cell types, growth …
tissue following injury involves dynamic interactions between multiple cell types, growth …
TGF-β-induced fibrosis: A review on the underlying mechanism and potential therapeutic strategies
Transforming growth factor-beta (TGF-β) plays multiple homeostatic roles in the regulation of
inflammation, proliferation, differentiation and would healing of various tissues. Many studies …
inflammation, proliferation, differentiation and would healing of various tissues. Many studies …
Targeting EMT in cancer: opportunities for pharmacological intervention
The spread of cancer cells to distant organs represents a major clinical challenge in the
treatment of cancer. Epithelial–mesenchymal transition (EMT) has emerged as a key …
treatment of cancer. Epithelial–mesenchymal transition (EMT) has emerged as a key …
[HTML][HTML] JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells
Abstract Epithelial-mesenchymal transition (EMT), a key step in the early stages of cancer
metastasis, is orchestrated by several signaling pathways, including IL-6/JAK/STAT3 and …
metastasis, is orchestrated by several signaling pathways, including IL-6/JAK/STAT3 and …
Uremic toxins induce kidney fibrosis by activating intrarenal renin–angiotensin–aldosterone system associated epithelial-to-mesenchymal transition
CY Sun, SC Chang, MS Wu - PloS one, 2012 - journals.plos.org
Background Uremic toxins are considered to have a determinant pathological role in the
progression of chronic kidney disease. The aim of this study was to define the putative …
progression of chronic kidney disease. The aim of this study was to define the putative …
[HTML][HTML] Appropriately differentiated ARPE-19 cells regain phenotype and gene expression profiles similar to those of native RPE cells
W Samuel, C Jaworski, OA Postnikova, RK Kutty… - Molecular …, 2017 - ncbi.nlm.nih.gov
Purpose The RPE cell line ARPE-19 provides a dependable and widely used alternative to
native RPE. However, replication of the native RPE phenotype becomes more difficult …
native RPE. However, replication of the native RPE phenotype becomes more difficult …
The role of actin dynamics and actin‐binding proteins expression in epithelial‐to‐mesenchymal transition and its association with cancer progression and evaluation …
M Izdebska, W Zielińska, D Grzanka… - BioMed research …, 2018 - Wiley Online Library
Metastasis causes death of 90% of cancer patients, so it is the most significant issue
associated with cancer disease. Thus, it is no surprise that many researchers are trying to …
associated with cancer disease. Thus, it is no surprise that many researchers are trying to …
Role of epithelial–mesenchymal transition in proliferative vitreoretinopathy
Proliferative vitreoretinopathy (PVR) is a potentially blinding fibrotic complication. It is
caused by the formation and contraction of epiretinal membranes (ERMs) that ultimately …
caused by the formation and contraction of epiretinal membranes (ERMs) that ultimately …
Iron, zinc, and copper in retinal physiology and disease
The essential trace metals iron, zinc, and copper play important roles both in retinal
physiology and disease. They are involved in various retinal functions such as …
physiology and disease. They are involved in various retinal functions such as …
Mechanisms of endothelial to mesenchymal transition in the retina in diabetes
Y Cao, B Feng, S Chen, Y Chu… - … & visual science, 2014 - iovs.arvojournals.org
Purpose.: Hyperglycemia-induced endothelial damage is a key pathogenetic factor in
diabetic retinopathy. Endothelial damage may lead to phenotypic changes in the cells …
diabetic retinopathy. Endothelial damage may lead to phenotypic changes in the cells …