Human red blood cells (RBCs) are approximately 8 μm in diameter, but must repeatedly
deform through capillaries as small as 2 μm in order to deliver oxygen to all parts of the …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

Background The human hemoglobin molecules are closely related proteins formed by
symmetric pairing of dimer polypeptide chains into a tetrameric functional structure: HbF …

In sickle cell disease (SCD), sickle hemoglobin (HbS) polymerizes upon deoxygenation,
resulting in sickling of red blood cells (RBCs). These sickled RBCs have strongly reduced …

Many hypotheses have been proposed to explain how a glutamate to valine substitution in
sickle haemoglobin (HbS) can cause sickle cell disease (SCD). We propose and document …

Decreased red cell deformability is characteristic of several disorders. In some cases, the
extent of defective deformability can predict severity of disease or occurrence of serious …

Hydroxyurea (HU) has been suggested to act as a nitric oxide (NO) donor in sickle cell
anemia (SCA). However, little is known about the HU NO-related effects on red blood cell …

Background Reduced red blood cell deformability (RBCD) is associated with diabetic
vascular complications, but early pathophysiological RBC changes and predictive …

Cell dehydration is a distinguishing characteristic of sickle cell disease and an important
contributor to disease pathophysiology. Due to the unique dependence of Hb S …

Introduction The unique red blood cell (RBC) properties that characterize the rare
neuroacanthocytosis syndromes (NAS) have prompted the exploration of osmotic gradient …