Depression in young people
A Thapar, O Eyre, V Patel, D Brent - The Lancet, 2022 - thelancet.com
Depression rates in young people have risen sharply in the past decade, especially in
females, which is of concern because adolescence is a period of rapid social, emotional …
females, which is of concern because adolescence is a period of rapid social, emotional …
Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
[HTML][HTML] Polygenic risk scores: from research tools to clinical instruments
Genome-wide association studies have shown unequivocally that common complex
disorders have a polygenic genetic architecture and have enabled researchers to identify …
disorders have a polygenic genetic architecture and have enabled researchers to identify …
The devastating clinical consequences of child abuse and neglect: increased disease vulnerability and poor treatment response in mood disorders
ETC Lippard, CB Nemeroff - American journal of psychiatry, 2020 - Am Psychiatric Assoc
A large body of evidence has demonstrated that exposure to childhood maltreatment at any
stage of development can have long-lasting consequences. It is associated with a marked …
stage of development can have long-lasting consequences. It is associated with a marked …
[HTML][HTML] The genetic basis of major depressive disorder
J Flint - Molecular psychiatry, 2023 - nature.com
The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …
The genetic basis of major depression
KM Kendall, E Van Assche, TFM Andlauer… - Psychological …, 2021 - cambridge.org
Major depressive disorder (MDD) is a common, debilitating, phenotypically heterogeneous
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
disorder with heritability ranges from 30% to 50%. Compared to other psychiatric disorders …
Reviewing the genetics of heterogeneity in depression: operationalizations, manifestations and etiologies
With progress in genome-wide association studies of depression, from identifying zero hits
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
in~ 16 000 individuals in 2013 to 223 hits in more than a million individuals in 2020 …
Genetic influences on eight psychiatric disorders based on family data of 4 408 646 full and half-siblings, and genetic data of 333 748 cases and controls
E Pettersson, P Lichtenstein, H Larsson… - Psychological …, 2019 - cambridge.org
BackgroundMost studies underline the contribution of heritable factors for psychiatric
disorders. However, heritability estimates depend on the population under study, diagnostic …
disorders. However, heritability estimates depend on the population under study, diagnostic …
A genetically informed Registered Report on adverse childhood experiences and mental health
Children who experience adversities have an elevated risk of mental health problems.
However, the extent to which adverse childhood experiences (ACEs) cause mental health …
However, the extent to which adverse childhood experiences (ACEs) cause mental health …
[HTML][HTML] Implementation and implications for polygenic risk scores in healthcare
JL Slunecka, MD van der Zee, JJ Beck, BN Johnson… - Human genomics, 2021 - Springer
Increasing amounts of genetic data have led to the development of polygenic risk scores
(PRSs) for a variety of diseases. These scores, built from the summary statistics of genome …
(PRSs) for a variety of diseases. These scores, built from the summary statistics of genome …