Hepatic insulin receptor: new views on the mechanisms of liver disease
Over 65% of people with obesity display the metabolic-associated fatty liver disease
(MAFLD), which can manifest as steatohepatitis, fibrosis, cirrhosis, or liver cancer. The …
(MAFLD), which can manifest as steatohepatitis, fibrosis, cirrhosis, or liver cancer. The …
FKBP ligands—where we are and where to go?
JM Kolos, AM Voll, M Bauder, F Hausch - Frontiers in pharmacology, 2018 - frontiersin.org
In recent years, many members of the FK506-binding protein (FKBP) family were
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …
increasingly linked to various diseases. The binding domain of FKBPs differs only in a few …
Moderate aerobic exercise training prevents the augmented hepatic glucocorticoid response induced by high-fat diet in mice
J Dassonvalle, F Díaz-Castro… - International journal of …, 2020 - mdpi.com
Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is
associated with the development of obesity and metabolic syndrome. However, it is not …
associated with the development of obesity and metabolic syndrome. However, it is not …
The FKBP51 glucocorticoid receptor co-chaperone: regulation, function, and implications in health and disease
Among the chaperones and co-chaperones regulating the glucocorticoid receptor (GR),
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
FK506 binding protein (FKBP) 51 is the most intensely investigated across different …
Stress-responsive FKBP51 regulates AKT2-AS160 signaling and metabolic function
The co-chaperone FKBP5 is a stress-responsive protein-regulating stress reactivity, and its
genetic variants are associated with T2D related traits and other stress-related disorders …
genetic variants are associated with T2D related traits and other stress-related disorders …
Glucocorticoids, their uses, sexual dimorphisms, and diseases: new concepts, mechanisms, and discoveries
GJ Martinez, M Appleton, ZA Kipp… - Physiological …, 2024 - journals.physiology.org
The normal stress response in humans is governed by the hypothalamic-pituitary-adrenal
(HPA) axis through heightened mechanisms during stress, raising blood levels of the …
(HPA) axis through heightened mechanisms during stress, raising blood levels of the …
Biological actions of the Hsp90-binding immunophilins FKBP51 and FKBP52
NR Zgajnar, SA De Leo, CM Lotufo, AG Erlejman… - Biomolecules, 2019 - mdpi.com
Immunophilins are a family of proteins whose signature domain is the peptidylprolyl-
isomerase domain. High molecular weight immunophilins are characterized by the …
isomerase domain. High molecular weight immunophilins are characterized by the …
FKBP51 and the molecular chaperoning of metabolism
KB Smedlund, ER Sanchez, TD Hinds - Trends in Endocrinology & …, 2021 - cell.com
The molecular chaperone FK506-binding protein 51 (FKBP51) is gaining attention as a
meaningful biomarker of metabolic dysfunction. This review examines the emerging …
meaningful biomarker of metabolic dysfunction. This review examines the emerging …
MicroRNA-27a promotes podocyte injury via PPARγ-mediated β-catenin activation in diabetic nephropathy
Z Zhou, J Wan, X Hou, J Geng, X Li, X Bai - Cell death & disease, 2017 - nature.com
Podocyte injury has a pivotal role in the pathogenesis of diabetic nephropathy (DN).
MicroRNA-27a (miR-27a), peroxisome proliferator-activated receptor γ (PPARγ) and β …
MicroRNA-27a (miR-27a), peroxisome proliferator-activated receptor γ (PPARγ) and β …