The'hallmarks of cancer'are generally accepted as a set of genetic and epigenetic
alterations that a normal cell must accrue to transform into a fully malignant cancer. It follows …

Melanoma is a life-threatening malignancy with poor prognosis and a relatively high burden
of mortality in advanced stages. The efficacy of current available therapeutic strategies is …

Background Sepsis is the leading cause of death in Intensive Care Units. Novel sepsis
biomarkers and targets for treatment are needed to improve mortality from sepsis …

Long noncoding RNAs (lncRNAs) play important regulatory roles in a variety of diseases,
including many tumors. However, the functional roles of these transcripts and mechanisms …

Abstract microRNAs (miRNAs) are known as a large group of short noncoding RNAs, which
structurally consist of 19–22 nucleotides in length and functionally act as one of the main …

Background Although p53 is inactivated by point mutations in many tumors, melanomas
infrequently harbor mutations in the p53 gene. Here we investigate the biological role of …

Melanoma is the utmost fatal kind of skin neoplasms. Molecular changes occurring during
the pathogenic processes of initiation and progression of melanoma are diverse and include …

MicroRNAs (miRNAs) are a small class of non‑coding RNAs that negatively regulate gene
expression, and are considered as new therapeutic targets for treating cancer. In this study …

Pancreatic cancer is one of the most malignant tumors that are difficult to diagnose at its
early stage and there is no effective therapy. Recent studies uncovered that many non …

Cystic fibrosis (CF) transmembrane conductance regulator (CFTR) is expressed in the
epithelial cells of a wide range of organs/tissues from which most cancers are derived …