Background When a patient arrives in the emergency department following a stroke, a
traumatic brain injury, or sudden cardiac arrest, there is no therapeutic drug available to help …

How to diagnose delayed cerebral ischaemia and symptomatic v... : Current Opinion in Critical
Care How to diagnose delayed cerebral ischaemia and symptomatic vasospasm and prevent …

Ischemic stroke (IS) is a multifactorial and heterogeneous neurological disorder with high
rate of death and long-term impairment. Despite years of studies, there are still no stroke …

Spreading depolarizations are characterized by abrupt, near-complete breakdown of the
transmembrane ion gradients, neuronal oedema, mitochondrial depolarization, glutamate …

Three decades of animal studies have reproducibly shown that hypothermia is profoundly
cerebroprotective during or after a central nervous system (CNS) insult. The success of …

Secondary brain injury after neurotrauma is comprised of a host of distinct, potentially
concurrent and interacting mechanisms that may exacerbate primary brain insult …

Cortical spreading depression or CSD is an electrophysiological phenomenon affecting
various perspectives of brain physiology such as ionic balance, neurotransmitter level, and …

Intracerebral hemorrhage (ICH) accounts for 10–15% of all strokes and leaves most
survivors with impairments. Fever, a rise in the thermoregulatory set point, complicates ICH …

In the noninvasive zero-heat-flux (ZHF) method, deep body temperature is brought to the
skin surface when an insulated temperature probe with servo-controlled heating on the skin …

Clinically, and legally, death is considered a well-defined state of the organism
characterized, at least, by a complete and irreversible cessation of brain activities and …