Osteosarcoma (OS) is the most common primary malignancy of bone and patients with
metastatic disease or recurrences continue to have very poor outcomes. Unfortunately, little …

Osteosarcoma is a rare tumor diagnosed at any age; however younger age is a common risk
factor. In addition, multiple factors are believed to contribute to higher rates of osteosarcoma …

Objective To identify the potential metabolic biomarkers of fluorosis and the pathogenesis of
fluorosis. Methods Sprague Dawley rats in this study were randomly divided into fluoride …

Fluorosis is a serious global public health problem. Interestingly, so far, there is no specific
drug treatment for the treatment of fluorosis. In this paper, the potential mechanisms of 35 …

Background Osteosarcoma (OS) is one of the most primary malignant bone tumors, mainly
attracting children and young adults. The microRNAs are mentioned to play vital roles in …

DNA methylation is an epigenetic modification of genome that is involved in many human
diseases. Recent studies revealed DNA methylation may be associated with fluorosis. This …

Exposure to high fluorine can cause toxicity in human and animals. Currently, there are no
systematic studies on effects of high fluorine on blood cellular immunity and humoral …

Chronic exposure to fluoride has been associated with the development of skeletal fluorosis.
Limited reports are available on fluoride induced histone modification. However, the role of …

An increased prevalence of cardiac complications has been observed in residents of
fluorosis endemic areas chronically exposed to fluoride. Fluoride induces soft tissue injury …

Manganese (Mn) is an essential trace element required for many physiological functions
including proper biochemical and cellular functioning of the central nervous system (CNS) …