The fruitless search for the cause of Crohn's disease has been conducted for more than a
century. Various theories, including autoimmunity, mycobacterial infection and aberrant …

Autophagy is subdivided into chaperone-mediated autophagy, microautophagy and
macroautophagy and is a highly conserved intracellular degradative pathway. It is crucial for …

Prevention of inflammatory bowel disease (IBD) relies on tight control of inflammatory, cell
death and autophagic mechanisms, but how these pathways are integrated at the molecular …

The T300A variant of ATG16L1 linked to Crohn's Disease impairs the cell biological pathway
of autophagy, yet up to 50% of humans are heterozygous for this disease risks allele. Here …

ABSTRACT A coding allele of ATG16L1 that increases the risk of Crohn disease (T300A;
rs2241880) impairs the interaction between the C-terminal WD40 domain (WDD) and …

Background We evaluated the impact of variations in ATG16L1 and NOD2 and genes on
serologic responses in patients with inflammatory bowel disease (IBD). Methods We …

Autophagy is a conserved self-eating process that delivers intracellular material to
lysosomes for degradation (Yu, Chen, & Tooze, 2018). Autophagy is activated by multiple …

[ES] La autofagia es una ruta de degradación celular que actúa como un mecanismo de
control de calidad del citoplasma, eliminando agregados proteicos, orgánulos dañados y …