The responses of patients to tumor therapies vary due to tumor heterogeneity. Tumor
stratification has been attracting increasing attention for accurately distinguishing between …

T cells are an essential part of the immune system with crucial roles in adaptive response
and the maintenance of tissue homeostasis. Depending on their microenvironment, T cells …

Aggregation-induced emission (AIE) enables “Turn-On” imaging generally through single
aggregation of the AIE luminogen (AIEgen). Dual aggregrations of the AIEgen might further …

Apoptosis, with a hallmark of upregulated protease Caspase-3, has been frequently imaged
with various probes to reveal the therapeutic efficiencies of different drugs. However …

Staphylococcus aureus (S. aureus) is able to hide within host cells to escape immune
clearance and antibiotic action, causing life‐threatening infections. To boost the therapeutic …

Granzyme B is an immune-related biomarker that closely correlates with cytotoxic T
lymphocytes (CTLs), and hence detecting the expression level of granzyme B can provide a …

Legumain, a lysosomal cysteine protease overexpressed in a variety of tumors, has been
considered a promising biomarker for various cancers. Precise detection of legumain activity …

Allograft rejection has always been a major obstacle in organ transplantation. The current
clinical diagnostic gold standard for allograft rejection is an invasive biopsy. However …

Near-infrared (NIR) fluorescence is a noninvasive, highly sensitive, and high-resolution
modality with great potential for in vivo imaging. Compared with “Always-On” probes …

Accurate diagnosis and effective treatment of tumors remain significant clinical challenges.
While fluorescence imaging is essential for tumor detection, it has limitations in terms of …