Saliva is one of the important body fluids that reflects normal internal characteristics and
disease state of an individual. As a multi-composition oral fluid, has high potential for the …

Cachexia, a multifactorial wasting syndrome, is highly prevalent among advanced-stage
cancer patients. Unlike weight loss in healthy humans, the progressive loss of body weight …

Automated detection of specific cells in three-dimensional datasets such as whole-brain light-
sheet image stacks is challenging. Here, we present DELiVR, a virtual reality-trained deep …

Cancer cachexia is a complex metabolic disorder accounting for~ 20% of cancer-related
deaths, yet its metabolic landscape remains unexplored. Here, we report a decrease in B …

Cachexia is a systemic wasting syndrome that increases cancer-associated mortality. How
cachexia progressively and differentially impacts distinct tissues is largely unknown. Here …

In pancreatic cancer, significant alterations occur in the local nervous system, including
axonogenesis, neural remodeling, perineural invasion, and perineural neuritis. Pancreatic …

Background Immune cells play a crucial role in the development and progression of
pancreatic cancer, yet the causal relationship remains uncertain due to complex immune …

Fibroblast activation protein-α (FAP-α) is a transmembrane serine protease that is attracting
significant interest as it is expressed by a subgroup of cancer-associated fibroblasts that play …

Pancreatic ductal adenocarcinoma (PDAC) is one of the most fatal types of solid tumors,
associated with a high prevalence of cachexia (~ 80%). PDAC-derived cachexia (PDAC-CC) …

Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor of the digestive
system which has a less than 1% 5-year survival rate. The pathogenesis of PDAC …