Genetically encoded fluorescent biosensors have revolutionized the study of cell signaling
and metabolism, as they allow for live-cell measurements with high spatiotemporal …

Building on current explorations in chronic optical neural interfaces, it is essential to address
the risk of photothermal damage in traditional optogenetics. By focusing on calcium …

Ferroptosis is iron-dependent oxidative cell death. Labile iron and polyunsaturated fatty acid
(PUFA)-containing lipids are two critical factors for ferroptosis execution. Many processes …

Fluorescent protein (FP)-based biosensors are genetically encoded tools that enable the
imaging of biological processes in the context of cells, tissues, or live animals. Though …

Monitoring neural activity in individual neurons is crucial for understanding neural circuits
and brain functions. The emergence of optical imaging technologies has dramatically …

Cellular function is controlled through intricate networks of signals, which lead to the myriad
pathways governing cell fate. Fluorescent biosensors have enabled the study of these …

Ca 2+ plays many critical roles in cell physiology and biochemistry, leading researchers to
develop a number of fluorescent small molecule dyes and genetically encodable probes that …

The prototypical calcium release-activated calcium (CRAC) channel, composed of STIM1
and Orai1, is a sought-after drug target for treating autoimmune disorders. Herein, we …

The Bxb1 bacteriophage serine DNA recombinase is an efficient tool for engineering
recombinant DNA into the genomes of cultured cells. Generally, a single engineered …

Genetically encoded fluorescent biosensors provide an attractive means of measuring
chemical changes in single cells on fast timescales (milliseconds to seconds). While their …