The term fibroblast has been used generally to describe spindle-shaped stromal cells of
mesenchymal origin that produce extracellular matrix, establish tissue structure, and form …

Fibrostenosing Crohn's disease (CD) represents a challenging clinical condition
characterized by the development of symptomatic strictures within the gastrointestinal tract …

Background Tumour necrosis factor superfamily protein 14 (TNFSF14), also called LIGHT, is
an important regulator of immunological and fibrosis diseases. However, its specific …

Objective New therapeutic strategies and paradigms are direly needed to treat pancreatic
cancer. The absence of a suitable pre-clinical animal model of pancreatic cancer is a major …

Fibroblasts are essential components of the stroma, sustaining a variety of tissues and being
key to the process of tissue repair after injury. Their role in tissue repair has been attributed …

Pancreatic tumors can be resistant to drug penetration due to high interstitial fluid pressure,
dense stroma, and disarrayed vasculature. Ultrasound-induced cavitation is an emerging …

Chimeric antigen receptor (CAR) T-cell therapy has resulted in remarkable clinical success
in the treatment of B-cell malignancies. However, its clinical efficacy in solid tumors is …

Eosinophilic esophagitis (EoE) is a chronic Th2-mediated inflammatory disease of the
esophagus characterized by signs and symptoms related to esophageal dysfunction and …

Fibroblasts acquire a proinflammatory phenotype in inflammatory bowel disease, but the
factors driving this process and how fibroblasts contribute to mucosal immune responses are …

Introduction Eosinophilic Esophagitis (EoE) is a chronic condition characterized by
eosinophilic inflammation of the esophagus which leads to esophageal dysfunction with …