Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors
V Mollace, C Muscoli, E Masini, S Cuzzocrea… - Pharmacological …, 2005 - ASPET
The biosynthesis and release of nitric oxide (NO) and prostaglandins (PGs) share a number
of similarities. Two major forms of nitric-oxide synthase (NOS) and cyclooxygenase (COX) …
of similarities. Two major forms of nitric-oxide synthase (NOS) and cyclooxygenase (COX) …
Hepatocellular carcinoma: epidemiology and clinical aspects
R Mazzanti, L Gramantieri, L Bolondi - Molecular aspects of medicine, 2008 - Elsevier
Liver cancer is one of the most frequent solid cancers that kills more than 650,000 people
around the world each year. Though great improvements have been done in last 10 years …
around the world each year. Though great improvements have been done in last 10 years …
[HTML][HTML] Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway
HW Lo, SC Hsu, M Ali-Seyed, M Gunduz, W Xia, Y Wei… - Cancer cell, 2005 - cell.com
Epidermal growth factor receptor (EGFR) exists in the nucleus of highly proliferative cells
where it functions as a transcription factor. Although EGFR has transactivational activity, it …
where it functions as a transcription factor. Although EGFR has transactivational activity, it …
Metformin inhibits P‐glycoprotein expression via the NF‐κB pathway and CRE transcriptional activity through AMPK activation
HG Kim, TT Hien, EH Han, YP Hwang… - British journal of …, 2011 - Wiley Online Library
BACKGROUND AND PURPOSE The expression of P‐glycoprotein (P‐gp), encoded by the
multidrug resistance 1 (MDR1) gene, is associated with the emergence of the MDR …
multidrug resistance 1 (MDR1) gene, is associated with the emergence of the MDR …
Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and cytokines via the NF-κB pathway
Background/Aims: Phyllanthusamarus is a herbal medicine traditionally applied in the
treatment of viral hepatitis. Aim of this study was to investigate potential anti-inflammatory …
treatment of viral hepatitis. Aim of this study was to investigate potential anti-inflammatory …
Resveratrol enhances chemosensitivity of doxorubicin in multidrug-resistant human breast cancer cells via increased cellular influx of doxorubicin
TH Kim, YJ Shin, AJ Won, BM Lee, WS Choi… - … et Biophysica Acta (BBA …, 2014 - Elsevier
Background Multidrug resistance is a major problem in the treatment of breast cancer, and a
number of studies have attempted to find an efficient strategy with which to overcome it. In …
number of studies have attempted to find an efficient strategy with which to overcome it. In …
Inducible nitric oxide synthase expression in human colorectal cancer: correlation with tumor angiogenesis
F Cianchi, C Cortesini, O Fantappiè, L Messerini… - The American journal of …, 2003 - Elsevier
To investigate the potential involvement of the nitric oxide (NO) pathway in colorectal
carcinogenesis, we correlated the expression and the activity of inducible nitric oxide …
carcinogenesis, we correlated the expression and the activity of inducible nitric oxide …
Nanoenabled tumor energy metabolism disorder via sonodynamic therapy for multidrug resistance reversal and metastasis inhibition
X Guo, P Tu, L Zhu, C Cheng, W Jiang… - … Applied Materials & …, 2022 - ACS Publications
Cancer multidrug resistance (MDR) is an important reason that results in chemotherapy
failure. As a main mechanism of MDR, overexpressed P-glycoprotein (P-gp) utilizes …
failure. As a main mechanism of MDR, overexpressed P-glycoprotein (P-gp) utilizes …
Cyclooxygenase-2 activation mediates the proangiogenic effect of nitric oxide in colorectal cancer
F Cianchi, C Cortesini, O Fantappie, L Messerini… - Clinical Cancer …, 2004 - AACR
Purpose: Up-regulation of both inducible nitric oxide synthase (iNOS) and cyclooxygenase-2
(COX-2) enzymes has been reported in colorectal cancer. We aimed at evaluating the …
(COX-2) enzymes has been reported in colorectal cancer. We aimed at evaluating the …
[HTML][HTML] Grape seed procyanidin reversal of p-glycoprotein associated multi-drug resistance via down-regulation of NF-κB and MAPK/ERK mediated YB-1 activity in …
B Zhao, Y Sun, S Wang, L Duan, Q Huo, F Ren, G Li - PloS one, 2013 - journals.plos.org
The expression and function of P-glycoprotein (P-gp) is associated with the phenotype of
multi-drug resistance (MDR), leading chemotherapy failure of patients suffered with cancer …
multi-drug resistance (MDR), leading chemotherapy failure of patients suffered with cancer …