One way to preserve a rare book is to lock it away from all potential sources of damage. Of
course, an inaccessible book is also of little use, and the paper and ink will continue to …

Replication stress is a complex phenomenon that has serious implications for genome
stability, cell survival and human disease. Generation of aberrant replication fork structures …

The ATR replication checkpoint ensures that stalled forks remain stable when replisome
movement is impeded. Using an improved iPOND protocol combined with SILAC mass …

Homology-dependent exchange of genetic information between DNA molecules has a
profound impact on the maintenance of genome integrity by facilitating error-free DNA …

Aberrant DNA replication is a major source of the mutations and chromosome
rearrangements that are associated with pathological disorders. When replication is …

The replication-stress response enables the DNA replication machinery to overcome DNA
lesions or intrinsic replication-fork obstacles, and it is essential to ensure faithful …

Proliferating cells rely on the so-called DNA replication checkpoint to ensure orderly
completion of genome duplication, and its malfunction may lead to catastrophic genome …

Genomes are transmitted faithfully from dividing cells to their offspring. Changes that occur
during DNA repair, chromosome duplication, and transmission or via recombination provide …

Repeated elements can be widely abundant in eukaryotic genomes, composing more than
50% of the human genome, for example. It is possible to classify repeated sequences into …

Billions of base pairs of DNA must be replicated trillions of times in a human lifetime.
Complete and accurate replication once and only once per cell division cycle is essential to …