Cyclooxygenases are a group of heme-containing isozymes (namely Cox-1 and Cox-2) that
catalyze the conversion of arachidonic acid to largely bioactive prostaglandins (PGs). Cox-1 …

Background and Objectives: Ketamine is a rapid-acting antidepressant with proven efficacy
as an add-on agent in unipolar and bipolar treatment-resistant depression. Although many …

We report the effects of aspartame on anxiety-like behavior, neurotransmitter signaling and
gene expression in the amygdala, a brain region associated with the regulation of anxiety …

The microglial response to a pathological microenvironment is hallmarked by a change in
cellular morphology. Following a pathological stimulus, microglia become reactive and …

Cyclooxygenase (COX) is a heme-containing enzyme that produces prostaglandins (PGs)
via a pathway known as the arachidonic acid (AA) cascade. Two isoforms of COX enzyme …

The conversion of adenosine to inosine in RNA editing (A-to-I RNA editing) is recognized as
a critical post-transcriptional modification of RNA by adenosine deaminases acting on RNAs …

Neuro-inflammation is known to initiate the underlying pathogenesis of several
neurodegenerative disorders which may progress to cognitive, behavioral, and functional …

Metabolic syndrome (MetS) is a public health problem and a risk of developing
cardiometabolic and neurodegenerative diseases. The biochemical-inflammatory …

Imipramine has been widely used as an antidepressant in the clinic over the years.
Unfortunately, it produces a detrimental effect on memory. At the same time, COX-2 …

Arachidonic acid (AA), an important polyunsaturated fatty acid in the brain, is hydrolyzed by
a direct action of phospholipase A2 (PLA2) or through the combined action of …