Endoplasmic reticulum stress and homeostasis in reproductive physiology and pathology

E Guzel, S Arlier, O Guzeloglu-Kayisli… - International journal of …, 2017 - mdpi.com
The endoplasmic reticulum (ER), comprises 60% of the total cell membrane and interacts
directly or indirectly with several cell organelles ie, Golgi bodies, mitochondria and …

Endoplasmic reticulum (ER) stress and unfolded protein response (UPR) in mammalian oocyte maturation and preimplantation embryo development

T Lin, JE Lee, JW Kang, HY Shin, JB Lee… - International journal of …, 2019 - mdpi.com
Mammalian oocytes and early embryos derived from in vitro production are highly
susceptible to a variety of cellular stresses. During oocyte maturation and preimplantation …

Aging and oocyte competence: A molecular cell perspective

AF Ferreira, M Soares… - WIREs Mechanisms …, 2023 - Wiley Online Library
Follicular microenvironment is paramount in the acquisition of oocyte competence, which is
dependent on two interconnected and interdependent processes: nuclear and cytoplasmic …

An active metabolite of the anti-COVID-19 drug molnupiravir impairs mouse preimplantation embryos at clinically relevant concentrations

Y Marikawa, VB Alarcon - Reproductive Toxicology, 2023 - Elsevier
Molnupiravir is a nucleoside analog antiviral that is authorized for use in the treatment of
COVID-19. For its therapeutic action, molnupiravir is converted after ingestion to the active …

Evaluating endoplasmic reticulum stress and unfolded protein response through the lens of ecology and evolution

KN Yap, KL Yamada, S Zikeli, H Kiaris… - Biological …, 2021 - Wiley Online Library
Considerable progress has been made in understanding the physiological basis for
variation in the life‐history patterns of animals, particularly with regard to the roles of …

Systematic in‐depth proteomic analysis of mitochondria‐associated endoplasmic reticulum membranes in mouse and human testes

X Wang, Y Wen, J Dong, C Cao, S Yuan - Proteomics, 2018 - Wiley Online Library
Mitochondria‐associated endoplasmic reticulum membranes (MAMs) regulate important
cellular functions including calcium signaling, bioenergetics, and apoptosis during …

The roles of endoplasmic reticulum stress response in female mammalian reproduction

Y Yang, X Pei, Y Jin, Y Wang, C Zhang - Cell and Tissue Research, 2016 - Springer
Endoplasmic reticulum stress (ERS) activates a protective pathway, called the unfold protein
response, for maintaining cellular homeostasis, but cellular apoptosis is triggered by …

Genomic Function of Estrogen Receptor β in Endometriosis

SJ Han, JE Lee, YJ Cho, MJ Park, BW O'Malley - Endocrinology, 2019 - academic.oup.com
Estrogen receptor (ER) β plays a critical role in endometriosis progression because
cytoplasmic ER β stimulates proinflammatory signaling in ectopic lesions and prevents …

Aneuploid embryonic stem cells drive teratoma metastasis

R Xiao, D Xu, M Zhang, Z Chen, L Cheng, S Du… - Nature …, 2024 - nature.com
Aneuploidy, a deviation of the chromosome number from euploidy, is one of the hallmarks of
cancer. High levels of aneuploidy are generally correlated with metastasis and poor …

Endoplasmic reticulum stress responses in placentation-A true balancing act

D Bastida-Ruiz, E Aguilar, A Ditisheim, L Yart, M Cohen - Placenta, 2017 - Elsevier
The unfolded protein response (UPR) is recognized as a key mechanism to promote protein
folding and processing in eukaryotes when endoplasmic reticulum stress (ERS) occurs …