Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead

A Grattoni, G Korbutt, AA Tomei, AJ García… - Nature Reviews …, 2024 - nature.com
Type 1 diabetes mellitus (T1DM) is a growing global health concern that affects
approximately 8.5 million individuals worldwide. T1DM is characterized by an autoimmune …

Immunoprotection Strategies in β‐Cell Replacement Therapy: A Closer Look at Porcine Islet Xenotransplantation

S Grimus, V Sarangova, PB Welzel, B Ludwig… - Advanced …, 2024 - Wiley Online Library
Type 1 diabetes mellitus (T1DM) is characterized by absolute insulin deficiency primarily
due to autoimmune destruction of pancreatic β‐cells. The prevailing treatment for T1DM …

Nano/genetically engineered cells for immunotherapy

J Shen, Y Zhou, L Yin - BMEMat, 2024 - Wiley Online Library
Immunotherapy has recently emerged as a promising therapeutic modality for the treatment
of various diseases such as cancer, inflammation, autoimmune diseases, and infectious …

Multifunctional hydroxyapatite nanobelt haystacks integrated neural stem cell spheroid for rapid spinal cord injury repair

M Hao, L Chen, J He, X Zhao, H Xia… - Advanced Functional …, 2023 - Wiley Online Library
Due to the unwarranted lifespan and differentiation, applying neural stem cells (NSCs) in
spinal cord injury (SCI) remains challenging. In this study, 3D bioactive hydroxyapatite (HAp) …

Advancing diabetes treatment: the role of mesenchymal stem cells in islet transplantation

L Mou, TB Wang, X Wang, Z Pu - Frontiers in Immunology, 2024 - frontiersin.org
Diabetes mellitus, a prevalent global health challenge, significantly impacts societal and
economic well-being. Islet transplantation is increasingly recognized as a viable treatment …

Human Platelet Lysate-Derived Nanofibrils as Building Blocks to Produce Free-Standing Membranes for Cell Self-Aggregation

CF Monteiro, MC Gomes, P Bharmoria, MG Freire… - ACS …, 2024 - ACS Publications
Amyloid-like fibrils are garnering keen interest in biotechnology as supramolecular
nanofunctional units to be used as biomimetic platforms to control cell behavior. Recent …

Local delivery of stem cell spheroids with protein/polyphenol self-assembling armor to improve myocardial infarction treatment via immunoprotection and …

C An, F Shao, C Long, Y Zhang, W Nie, R Zeng, Z Dou… - Biomaterials, 2024 - Elsevier
Stem cell therapies have shown great potential for treating myocardial infarction (MI) but are
limited by low cell survival and compromised functionality due to the harsh …

Current perspectives on the dynamic culture of mesenchymal stromal/stem cell spheroids

Y Ohori-Morita, A Ashry, K Niibe… - Stem Cells Translational …, 2024 - academic.oup.com
Mesenchymal stromal/stem cells (MSCs) are promising candidates for regenerative
medicine owing to their self-renewal properties, multilineage differentiation …

[HTML][HTML] Vascular and immune interactions in islets transplantation and 3D islet models

A Migliorini, MC Nostro - Current Opinion in Genetics & Development, 2024 - Elsevier
The aim of regenerative medicine is to restore specific functions to damaged cells or tissues.
A crucial aspect of success lies in effectively reintegrating these cells or tissues within the …

Scalable and Uniform Fabrication of Dexamethasone-Eluting Depot-Engineered Stem Cell Spheroids as a Microtissue Construct to Target Bone Regeneration

TT Nguyen, MT Phuong, M Shrestha… - … applied materials & …, 2023 - ACS Publications
Potentiation of stem cell potency is critical for successful tissue engineering, especially for
bone regeneration. Three-dimensional cell culture and bioactive molecule co-delivery with …