▪ Abstract Trk receptors are a family of three receptor tyrosine kinases, each of which can be
activated by one or more of four neurotrophins—nerve growth factor (NGF), brain-derived …

Fluorescent probes are one of the cornerstones of real-time imaging of live cells and a
powerful tool for cell biologists. They provide high sensitivity and great versatility while …

Recent structural studies of epidermal growth factor receptor (EGFR) family extracellular
regions have identified an unexpected mechanism for ligand-induced receptor dimerization …

Biomedical photonics is defined as the science of harnessing light and other forms of radiant
energy to address problems in medicine and biology. The field has experienced explosive …

Oxidants such as H2O2 are connected to lymphocyte activation, but the molecular
mechanisms behind this phenomenon are less clear. Here, I review data suggesting that by …

We show that the specific subcellular distribution of H-and Nras guanosine triphosphate–
binding proteins is generated by a constitutive de/reacylation cycle that operates on …

The mutation and overexpression of the epidermal growth factor receptor (EGFR) are
associated with the development of a variety of cancers, making this prototypical …

In fluorescence microscopy, the fluorescence emission can be characterised not only by
intensity and position, but also by lifetime, polarization and wavelength. Fluorescence …

The complexity and specificity of many forms of signal transduction are widely suspected to
require spatial microcompartmentation of protein kinase and phosphatase activities, yet …

Two‐photon excitation microscopy is an alternative to confocal microscopy that provides
advantages for three‐dimensional and deep tissue imaging. This unit will describe the basic …