The MDM2 and MDMX (also known as HDMX and MDM4) proteins are deregulated in many
human cancers and exert their oncogenic activity predominantly by inhibiting the p53 tumour …

That senescence is rarely, if ever, observed in natural populations is an oft-quoted fallacy
within bio-gerontology. We identify the roots of this fallacy in the otherwise seminal works of …

Just over 25 years ago, MYC, the human homologue of a retroviral oncogene, was
identified. Since that time, MYC research has been intense and the advances impressive …

Apoptosis plays an important role in development and maintenance of tissue homeostasis.
Intensive efforts have been made to explore the molecular mechanisms of the apoptotic …

For decades immunologists have relied heavily on the mouse model for their experimental
designs. With the realization of the important role innate immunity plays in orchestrating …

Mouse double minute 2 (MDM2) is a critical negative regulator of the tumor suppressor p53,
playing a key role in controlling its transcriptional activity, protein stability, and nuclear …

Cancers are rare because their evolution is actively restrained by a range of tumour
suppressors. Of these p53 seems unusually crucial as either it or its attendant upstream or …

The pathogenesis of mycosis fungoides (MF), the most common cutaneous T-cell lymphoma
(CTCL), is unknown. Although genetic alterations have been identified, none are considered …

Histone H2AX becomes phosphorylated in chromatin domains flanking sites of DNA double-
strand breakage associated with γ-irradiation, meiotic recombination, DNA replication, and …

A paradox for the cancer biology field has been the revelation that oncogenes, once thought
to simply provide advantages to a cancer cell, actually put it at dire risk of cell suicide. Myc is …