The pulmonary endothelium is a metabolically active continuous monolayer of squamous
endothelial cells that internally lines blood vessels and mediates key processes involved in …

The cellular response to oxygen deprivation is governed largely by a family of transcription
factors known as Hypoxia Inducible Factors (HIFs). This review focuses on the molecular …

Oxygen homeostasis represents an organizing principle for understanding metazoan
evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) …

Hypoxia-inducible factors (HIFs) are broadly expressed in human cancers, and HIF1α and
HIF2α were previously suspected to promote tumour progression through largely …

The vascular network delivers oxygen (O2) and nutrients to all cells within the body. It is
therefore not surprising that O2 availability serves as a primary regulator of this complex …

A classic physiologic response to systemic hypoxia is the increase in red blood cell
production. Hypoxia-inducible factors (HIFs) orchestrate this response by inducing cell-type …

Hypoxia is an inadequate oxygen supply to tissues and cells, which can restrict their
function. The hypoxic response is primarily mediated by the hypoxia-inducible transcription …

Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis
during embryogenesis, skeletal growth and reproductive functions. VEGF has also been …

Blood vessels constitute the first organ in the embryo and form the largest network in our
body but, sadly, are also often deadly. When dysregulated, the formation of new blood …

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and
an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major …