Wnt, a secreted glycoprotein, has an approximate molecular weight of 40 kDa, and it is a
cytokine involved in various biological phenomena including ontogeny, morphogenesis …

Mesenchymal stem cells (MSCs) derived from adipose tissue, bone marrow, cord blood, and
other tissues, have recently attracted much attention as potential therapeutic agents in …

This review describes the historical emergence of the concept of bone marrow
mesenchymal stem cells (MSCs), summarizing data on Wolf and Trentin's hematopoietic …

Increasingly, human mesenchymal malignancies are being classified by the abnormalities
that drive their pathogenesis. Although many of these aberrations are highly prevalent within …

Transcription factor fusion proteins can transform cells by inducing global changes of the
transcriptome, often creating a state of oncogene addiction. Here, we investigate the role of …

Translocated in liposarcoma, Ewing's sarcoma and TATA-binding protein-associated factor
15 constitute an interesting and important family of proteins known as the TET proteins. The …

STAG2, a cohesin family gene, is among the most recurrently mutated genes in cancer.
STAG2 loss of function (LOF) is associated with aggressive behavior in Ewing sarcoma, a …

Ewing's sarcoma is a highly aggressive bone and soft tissue tumor of children and young
adults. At the molecular genetic level Ewing's sarcoma is characterized by a balanced …

YAP and TAZ are intracellular messengers communicating multiple interacting extracellular
biophysical and biochemical cues to the transcription apparatus in the nucleus and back to …

Mesenchymal stem cells (MSCs) are multipotent progenitor cells that participate in the
structural and functional maintenance of connective tissues under normal homeostasis …