UV-radiations are the invisible part of light spectra having a wavelength between visible rays
and X-rays. Based on wavelength, UV rays are subdivided into UV-A (320–400 nm), UV-B …

Ancient civilizations understood that sunlight provides visibility, warmth, health and vitality.
Their understanding of how sunlight provides these life-sustaining influences was immersed …

Background Basal cell carcinoma (BCC) of the skin is the most common human cancer. The
genetic alterations underlying BCC development are only partly understood. Objectives To …

Abstract Cyclobutane pyrimidine dimers and (6–4) photoproducts are the two major classes
of lesions produced in DNA by UVB and UVC irradiation. Their distribution along genes is …

The transition from a normal cell to a neoplastic cell is a complex process and involves both
genetic and epigenetic changes. The process of carcinogenesis begins when the DNA is …

Many human skin tumors contain mutated p53 genes that probably result from UV exposure.
To investigate the link between UV exposure and p53 gene mutation, we developed two …

Skin cancer is the most common neoplasm in Caucasians in the United States with a lifetime
risk nearly equal to that of all other cancers combined (1). More than 800,000 people are …

Mutations in PATCHED (PTC), the human homolog of the Drosophila patched gene, have
been identified in most exons of the gene in patients with the basal cell nevus syndrome and …

Epidemiologic evidence on the relation between sunlight and cancer is reviewed. Strong
evidence implicates sunlight as a cause of skin cancer, although, for melanoma and basal …

The p53 tumor suppressor gene and gene product are among the most diverse and complex
molecules involved in cellular functions. Genetic alterations within the p53 gene have been …