▪ Abstract Hemagglutinin (HA) is the receptor-binding and membrane fusion glycoprotein of
influenza virus and the target for infectivity-neutralizing antibodies. The structures of three …

Over the last ten years, there has been considerable research interest in the development of
polymeric carriers for biomedicine. Such delivery systems have the potential to significantly …

Recent research has provided an abundance of new information on membrane
biochemistry. Now more than ever, it is essential to update our current understanding of …

All organisms need protection against microorganisms, eg bacteria, viruses and fungi. For
many years, attention has been focused on adaptive immunity as the main antimicrobial …

Enveloped viruses enter cells by protein-mediated membrane fusion. For influenza virus,
membrane fusion is regulated by the conformational state of the hemagglutinin (HA) protein …

▪ Abstract Significant progress has been made in elucidating the mechanisms of viral
membrane fusion proteins; both those that function at low, as well as those that function at …

ABSTRACT A synthetic peptide, DP178, containing amino acids 127 to 162 of the human
immunodeficiency virus type 1 (HIV-1) gp41 Env glycoprotein, is a potent inhibitor of virus …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the devastating global COVID-19 pandemic announced by WHO in March 2020. Through …

Entry of SARS-CoV-2 into a host cell is mediated by spike, a class I viral fusion protein
responsible for merging the viral and host cell membranes. Recent studies have revealed …

Background: Sensitive and selective molecular recognition is important throughout biology.
Certain organisms and toxins use specific binding at the cell surface as a first step towards …