Articular cartilage is commonly described as a tissue that is made of up to 80% water, is
devoid of blood vessels, nerves, and lymphatics, and is populated by only one cell type, the …

Much of our understanding of the biological mechanisms that underlie cellular functions,
such as migration, differentiation and force-sensing has been garnered from studying cells …

Silk fibroin hydrogels crosslinked through di‐tyrosine bonds are clear, elastomeric
constructs with immense potential in regenerative medicine applications. In this study …

Three–dimensional, microperiodic scaffolds of regenerated silk fibroin have been fabricated
for tissue engineering by direct ink writing. The ink, which consisted of silk fibroin solution …

OBJECTIVE: Articular chondrocytes respond to chemical and mechanical signals depending
on their zone of origin with respect to distance from the tissue surface. However, little is …

Endochondral ossification is initiated by the differentiation of mesenchymal precursor cells to
chondrocytes (chondrogenesis). This process is characterized by a strong interdependence …

Cell differentiation, adhesion, and orientation are known to influence the functionality of both
natural and engineered tissues, such as articular cartilage. Several attempts have been …

A biomaterial scaffold acting as a functional substitute for the native extracellular matrix
provides space for cell accommodation. In this study, we seeded chondrocytes, isolated from …

The three‐dimensional architecture of cells in the annulus fibrosus was studied by a
systematic, histological examination using antibodies to cytoskeletal components, in …

The basic molecular characteristics of intervertebral disc cells are still poorly defined. This
study compared the phenotypes of nucleus pulposus (NP), annulus fibrosus (AF) and …