Structure and function of invertebrate Kunitz serine protease inhibitors

S Ranasinghe, DP McManus - Developmental & Comparative Immunology, 2013 - Elsevier
Kunitz type proteins are an important group of ubiquitous protease inhibitors found spanning
the evolutionary tree from microbes to mammals. These proteins can have single or multiple …

Twenty-five-year research progress in hookworm excretory/secretory products

AMI Abuzeid, X Zhou, Y Huang, G Li - Parasites & vectors, 2020 - Springer
Hookworm infection is a major public health problem that threatens about 500 million people
throughout tropical areas of the world. Adult hookworms survive for many years in the host …

[HTML][HTML] Genome of the human hookworm Necator americanus

YT Tang, X Gao, BA Rosa, S Abubucker… - Nature …, 2014 - nature.com
The hookworm Necator americanus is the predominant soil-transmitted human parasite.
Adult worms feed on blood in the small intestine, causing iron-deficiency anemia …

Ancient diversity in host-parasite interaction genes in a model parasitic nematode

L Stevens, I Martínez-Ugalde, E King, M Wagah… - Nature …, 2023 - nature.com
Host-parasite interactions exert strong selection pressures on the genomes of both host and
parasite. These interactions can lead to negative frequency-dependent selection, a form of …

Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) …

JP Hewitson, Y Harcus, J Murray, M van Agtmaal… - Journal of …, 2011 - Elsevier
The intestinal helminth parasite, Heligmosomoides polygyrus bakeri offers a tractable
experimental model for human hookworm infections such as Ancylostoma duodenale and …

Intestinal helminth infection, anemia, undernutrition and academic performance among school children in northwestern Ethiopia

A Degarege, B Erko, Y Negash, A Animut - Microorganisms, 2022 - mdpi.com
This study examined the prevalence and intensity of intestinal helminth infections and their
association with anemia, undernutrition, and academic performance among school children …

[HTML][HTML] Effectiveness of albendazole for hookworm varies widely by community and correlates with nutritional factors: a cross-sectional study of school-age children in …

D Humphries, S Nguyen, S Kumar… - The American journal …, 2017 - ncbi.nlm.nih.gov
Mass drug administration (MDA) targeting school-age children is recommended by the
World Health Organization for the global control of soil-transmitted helminth (STH) infections …

Functional expression of a novel Kunitz type protease inhibitor from the human blood fluke Schistosoma mansoni

SL Ranasinghe, K Fischer, GN Gobert, DP McManus - Parasites & Vectors, 2015 - Springer
Background Schistosomes are able to survive for prolonged periods in the blood system,
despite continuous contact with coagulatory factors and mediators of the host immune …

Chronic helminth infections may negatively influence immunity against tuberculosis and other diseases of public health importance

D Elias, S Britton, A Kassu, H Akuffo - Expert review of anti-infective …, 2007 - Taylor & Francis
Tuberculosis (TB) has once again become a major public health threat owing to the
combined effects of deteriorating socioeconomic situations and the emergence of the …

An atypical and functionally diverse family of Kunitz-type cysteine/serine proteinase inhibitors secreted by the helminth parasite Fasciola hepatica

D Smith, K Cwiklinski, H Jewhurst, IG Tikhonova… - Scientific Reports, 2020 - nature.com
Fasciola hepatica is a global parasite of humans and their livestock. Regulation of parasite-
secreted cathepsin L-like cysteine proteases associated with virulence is important to fine …