The simultaneous evolution of multiple aptamers can drastically increase the speed of
aptamer discovery. Most previous studies used the same concentration for different targets …

Salicylic acid (SA) is a hydrolysis product and an active form of aspirin, and SA is found in a
range of fruits and other food products. For food and drug and analysis there is a strong …

In this study, capillary sieving electrophoresis (CSE) using polymer solutions was used to
evaluate the structural changes in nucleic acids upon complexation with small molecules. As …

Lysozymes are a highly popular protein target for the development of aptamer-based
biosensors. Because a lysozyme is a polycation and DNA is a polyanion, it is essential to …

Effective monitoring of ocular drugs is crucial for personalized medicine and improving drug
delivery efficacy. However, traditional methods face difficulties in detecting low drug …

We serendipitously discovered Zn2+-binding aptamers when selecting insulin aptamers.
The Zn-1 aptamer binds to Zn2+ with a dissociation constant (Kd) of~ 1 µM, and has 450-fold …

Aptamer switches as effective biosensing tools have become a focal point of research in
engineered aptasensors. Intramolecular aptamer switches are more versatile, affordable …

We recently reported that some adenosine binding aptamers can also bind caffeine and
theophylline with around 20‐fold lower affinities. This discovery led to the current work to …

Background Xiaoyaosan has been used to treat mental disorders in China for thousands of
years. Xiaoyaosan may also provide a potential therapeutic advantage in the treatment of …

Citrate is a key metabolite and nutrient in humans. Its level is associated with many diseases
from tumor growth to bone diseases. Detection of citrate has relied on its high negative …