The Martini model, a coarse‐grained force field for molecular dynamics simulations, has
been around for nearly two decades. Originally developed for lipid‐based systems by the …

Membrane proteins have diverse functions within cells and are well-established drug
targets. The advances in membrane protein structural biology have revealed drug and lipid …

Lipid-protein interactions play an important direct role in the function of many membrane
proteins. We argue they are key players in membrane structure, modulate membrane …

Membrane lipids extensively modulate the activation gating of voltage-gated potassium
channels (KV), however, much less is known about the mechanisms of ceramide and …

Abstract Phosphatidylinositol-4, 5-bisphosphate (PIP2) is a signaling lipid which regulates
voltage-gated Kv7/KCNQ potassium channels. Altered PIP2 sensitivity of neuronal Kv7. 2 …

Numerous non-cardiovascular drugs have a potential to induce life-threatening torsades de
pointes (TdP) ventricular cardiac arrhythmias by blocking human ether-à-go-go-related gene …

Molecular dynamics simulations of cellular membranes have come a long way—from simple
model lipid bilayers to multicomponent systems capturing the crowded and complex nature …

High cardiac levels of total ceramides are noted in heart failure. In the plasma, C16: 0/C24: 0
ceramides may be a valuable biomarker of preclinical left ventricular dysfunction …

We describe methods to analyze lipid distributions and curvature in membranes with
complex lipid mixtures and embedded membrane proteins. We discuss issues involved in …

General lipid-lowering strategies exhibit clinical benefit, however, adverse effects and low
adherence of relevant pharmacotherapies warrants the investigation into distinct avenues …