The Emerging Role of LPA as an Oncometabolite
T Karalis, G Poulogiannis - Cells, 2024 - mdpi.com
Lysophosphatidic acid (LPA) is a phospholipid that displays potent signalling activities that
are regulated in both an autocrine and paracrine manner. It can be found both extra-and …
are regulated in both an autocrine and paracrine manner. It can be found both extra-and …
[HTML][HTML] Characterization and translational development of IOA-289, a novel autotaxin inhibitor for the treatment of solid tumors
MA Deken, K Niewola-Staszkowska… - Immuno-Oncology and …, 2023 - Elsevier
Background Autotaxin-lysophosphatidic acid (ATX-LPA) signaling has a predominant role in
immunological and fibrotic processes, including cancer. Several ATX inhibitors and LPA …
immunological and fibrotic processes, including cancer. Several ATX inhibitors and LPA …
Entering, Linked with the Sphinx: Lysophosphatidic Acids Everywhere, All at Once, in the Oral System and Cancer
DR Cerutis, MD Weston, T Miyamoto - International journal of molecular …, 2023 - mdpi.com
Oral health is crucial to overall health, and periodontal disease (PDD) is a chronic
inflammatory disease. Over the past decade, PDD has been recognized as a significant …
inflammatory disease. Over the past decade, PDD has been recognized as a significant …
[HTML][HTML] Deleting autotaxin in LysM+ myeloid cells impairs innate tumor immunity in models of metastatic melanoma
MA Dacheux, DD Norman, Y Shin, GJ Tigyi, SC Lee - Iscience, 2024 - cell.com
Autotaxin (ATX) is a lysophospholipase D that generates lysophosphatidic acid (LPA) and
regulates cancer metastasis, therapeutic resistance, and tumor immunity. We found that …
regulates cancer metastasis, therapeutic resistance, and tumor immunity. We found that …
E2F7 drives autotaxin/Enpp2 transcription via chromosome looping: Repression by p53 in murine but not in human carcinomas
KH Lin, SC Lee, MA Dacheux, DD Norman… - The FASEB …, 2023 - Wiley Online Library
Dysregulation of the autotaxin (ATX, Enpp2)‐lysophosphatidic acid (LPA) signaling in
cancerous cells contributes to tumorigenesis and therapy resistance. We previously found …
cancerous cells contributes to tumorigenesis and therapy resistance. We previously found …
Track‐Etched Membranes for Drug Pharmaceutical Research
K Cuanalo-Contreras, AMR Hogrebe… - Chemie Ingenieur …, 2023 - Wiley Online Library
Over the last decades, the incorporation of membranes into micro physiological systems
used for pharmaceutical research and drug development has grown significantly. One …
used for pharmaceutical research and drug development has grown significantly. One …
Metastatic Progression of Human Melanoma
J Tímár, A Ladányi - Cancers, 2023 - mdpi.com
This Topical Collection, comprising 13 papers (10 original articles and 3 reviews),
addresses various aspects of the field of melanoma progression: genomic and proteomic …
addresses various aspects of the field of melanoma progression: genomic and proteomic …
The prognostic and biological importance of chromatin regulation-related genes for lung cancer is examined using bioinformatics and experimentally confirmed
S Ren, H Yu - Pathology-Research and Practice, 2023 - Elsevier
Background The pathogenesis and clinical diagnosis of lung adenocarcinoma (LUAD), a
malignant illness with substantial morbidity and mortality, are still being investigated. Genes …
malignant illness with substantial morbidity and mortality, are still being investigated. Genes …
[引用][C] Metastatic Progression of Human Melanoma. Cancers 2023, 15, 1225
J Tímár, A Ladányi - 2023 - europepmc.org
This Topical Collection, comprising 13 papers (10 original articles and 3 reviews),
addresses various aspects of the field of melanoma progression: genomic and proteomic …
addresses various aspects of the field of melanoma progression: genomic and proteomic …