Fundamentally precision oncology illustrates the path in which molecular profiling of tumors
can illuminate their biological behavior, diversity, and likely outcomes by identifying distinct …

DNA methylation is a fundamental mechanism of epigenetic control in cells and its
dysregulation is strongly implicated in cancer development. Cancers possess an extensively …

Motivation Understanding the genomic heterogeneity of tumors is an important task in
computational oncology, especially in the context of finding personalized treatments based …

Energy metabolism is a fundamental aspect of the aggressiveness and invasiveness of
breast cancer (BC), the neoplasm that most affects women worldwide. Nonetheless, the …

Background Emerging evidence supports tumor tissue-based comprehensive genomic
profiling (CGP) in metastatic colorectal cancer (mCRC). Data on liquid biopsy-based …

The emergence of targeted therapies in non-small-cell lung cancer (NSCLC), including
inhibitors of epidermal growth factor receptor (EGFR) tyrosine kinase, has increased the …

Background BRAF V600 mutations are the epitome of targeted therapy. However, not much
is known about non-V600 mutations. Using the new data infrastructure of the Swiss …

Abstract Therapeutic agents targeting Human Epidermal Growth Factor Receptor 2 (HER2)
demonstrated to positively impact the prognosis of HER2-positive breast cancer. HER2 …

Background Genomic tumour profiling has a crucial role in the management of patients with
solid cancers, as it helps selecting and prioritising therapeutic interventions based on …

In current clinical practice, effective cancer testing and screening paradigms are limited to
specific types of cancer, exhibiting varying efficiency, acceptance, and adherence. Cell-free …