Ru (II)/amino acid complexes inhibit the progression of breast cancer cells through multiple mechanism-induced apoptosis

F Mello-Andrade, APM Guedes, WC Pires… - Journal of Inorganic …, 2022 - Elsevier
For some cancer subtypes, such as triple-negative breast cancer, there are no specific
therapies, which leads to a poor prognosis associated with invasion and metastases …

[HTML][HTML] Acute toxic effects of ruthenium (II)/amino acid/diphosphine complexes on Swiss mice and zebrafish embryos

F Mello-Andrade, CG Cardoso, CR e Silva… - Biomedicine & …, 2018 - Elsevier
Anticancer potential of ruthenium complexes has been widely investigated, but safety
evaluation studies are still scarce. Despite of ruthenium-based anticancer agents are known …

In vitro cytotoxicity and in vivo zebrafish toxicity evaluation of Ru (ii)/2-mercaptopyrimidine complexes

VS Velozo-Sá, LR Pereira, AP Lima… - Dalton …, 2019 - pubs.rsc.org
In this paper, four new ruthenium complexes,[Ru (N–S)(dppm) 2] PF6 (1),[Ru (N–S)(dppe) 2]
PF6 (2),[Ru (N–S) 2 (dppp)](3) and [Ru (N–S) 2 (PPh3) 2](4)[dppm= 1, 1-bis …

Cytotoxic activity and structural features of Ru (II)/phosphine/amino acid complexes

ER Dos Santos, AE Graminha, MS Schultz… - Journal of inorganic …, 2018 - Elsevier
Thirteen new ruthenium amino acid complexes were synthesized and characterized. They
were obtained by the reaction of α-amino acids (AA) with [RuCl 2 (PP)(NN)], where PP= 1, 4 …

In vitro and in vivo antitumor activity of a novel carbonyl ruthenium compound, the ct-[RuCl (CO)(dppb)(bipy)] PF6 [dppb= 1, 4-bis (diphenylphosphine) butane and …

AP Carnizello, MIF Barbosa, M Martins… - Journal of inorganic …, 2016 - Elsevier
This study performed in vitro and in vivo biological assays of the ruthenium (II) compound ct-
[RuCl (CO)(dppb)(bipy)] PF 6 (where, dppb= 1, 4-bis (diphenylphosphine) butane and bipy …

Anticancer activity and mechanism of bis-pyrimidine based dimetallic Ru (II)(η6-p-cymene) complex in human non-small cell lung cancer via p53-dependent pathway

MZ Bhatti, A Ali, HQ Duong, J Chen… - Journal of inorganic …, 2019 - Elsevier
Non-small cell lung cancer (NSCLC) is the most common cancer worldwide, which is related
with poor prognosis and resistance to chemotherapy. Notably, ruthenium-based complexes …

Ruthenium (II) complexes with N, O-chelating proline and threonine ligands cause selective cytotoxicity by the induction of genomic instability, cell cycle arrest and …

IH de Sousa, VNS Campos, AAM Vale… - Toxicology in Vitro, 2020 - Elsevier
Ruthenium complexes are being considered as novel chemotherapeutic alternatives for
cancer treatment. In our study, we assessed the antitumoral activities of novel ruthenium …

Investigation of acyclovir-loaded, acrylamide-based hydrogels for potential use as vaginal ring

F Sabbagh, II Muhamad, Z Nazari, P Mobini… - Materials Today …, 2018 - Elsevier
In the current research, based on the investigation of the drug-loaded hydrogels, the
maximum content of acyclovir loading in polymer consequently relates to the pH at which the …

Antitumor effectiveness and mechanism of action of Ru (II)/amino acid/diphosphine complexes in the peritoneal carcinomatosis progression

F Mello-Andrade, WL da Costa, WC Pires… - Tumor …, 2017 - journals.sagepub.com
Peritoneal carcinomatosis is considered as a potentially lethal clinical condition, and the
therapeutic options are limited. The antitumor effectiveness of the [Ru (l-Met)(bipy)(dppb)] …

Ruthenium complexes show promise when submitted to toxicological safety tests using alternative methodologies

TM Teixeira, IG Arraes, DC Abreu, KM Oliveira… - European Journal of …, 2021 - Elsevier
The number of cancer cases continues to increase worldwide, and unfortunately the main
systemic treatments available have numerous of side effects. Ruthenium complexes have …