IgA: structure, function, and developability

P de Sousa-Pereira, JM Woof - Antibodies, 2019 - mdpi.com
Immunoglobulin A (IgA) plays a key role in defending mucosal surfaces against attack by
infectious microorganisms. Such sites present a major site of susceptibility due to their vast …

IgA and FcαRI: pathological roles and therapeutic opportunities

A Breedveld, M Van Egmond - Frontiers in immunology, 2019 - frontiersin.org
Immunoglobulin A (IgA) is the most abundant antibody class present at mucosal surfaces.
The production of IgA exceeds the production of all other antibodies combined, supporting …

The function of immunoglobulin A in immunity

JM Woof, MA Kerr - The Journal of Pathology: A Journal of the …, 2006 - Wiley Online Library
The vast surfaces of the gastrointestinal, respiratory, and genitourinary tracts represent
major sites of potential attack by invading micro‐organisms. Immunoglobulin A (IgA), as the …

Structure and function relationships in IgA

JM Woof, MW Russell - Mucosal immunology, 2011 - nature.com
Immunoglobulin A (IgA) has a critical role in immune defense particularly at the mucosal
surfaces, and is equipped to do so by the unique structural attributes of its heavy chain and …

Human antibody–Fc receptor interactions illuminated by crystal structures

JM Woof, DR Burton - Nature Reviews Immunology, 2004 - nature.com
Immunoglobulins couple the recognition of invading pathogens with the triggering of potent
effector mechanisms for pathogen elimination. Different immunoglobulin classes trigger …

Mucosal immunoglobulins

JM Woof, J Mestecky - Mucosal immunology, 2015 - Elsevier
Immunoglobulins (Igs) play key roles in immune protection of mucosal surfaces that form an
immense and vulnerable interface with the environment. In humans, the principal Ig in most …

Surface Proteins of Streptococcus agalactiae and Related Proteins in Other Bacterial Pathogens

G Lindahl, M Stålhammar-Carlemalm… - Clinical microbiology …, 2005 - Am Soc Microbiol
Streptococcus agalactiae (group B Streptococcus) is the major cause of invasive bacterial
disease, including meningitis, in the neonatal period. Although prophylactic measures have …

[HTML][HTML] Tenebrio molitor and Zophobas morio full-fat meals as functional feed additives affect broiler chickens' growth performance and immune system traits

A Benzertiha, B Kierończyk, P Kołodziejski… - Poultry science, 2020 - Elsevier
This study was conducted to investigate the effect of insect full-fat meals (Tenebrio molitor
and Zophobas morio larvae), added “on top” of a complete diet or calculated into diets, on …

IgA and FcαRI: Versatile players in homeostasis, infection, and autoimmunity

MMJ van Gool, M van Egmond - ImmunoTargets and Therapy, 2021 - Taylor & Francis
Mucosal surfaces constitute the frontiers of the body and are the biggest barriers of our body
for the outside world. Immunoglobulin A (IgA) is the most abundant antibody class present at …

The staphylococcal superantigen-like protein 7 binds IgA and complement C5 and inhibits IgA-FcαRI binding and serum killing of bacteria

R Langley, B Wines, N Willoughby, I Basu… - The Journal of …, 2005 - journals.aai.org
The staphylococcal superantigen-like proteins (SSLs) are close relatives of the
superantigens but are coded for by a separate gene cluster within a 19-kb region of the …