Complete and accurate DNA replication requires the progression of replication forks through
DNA damage, actively transcribed regions, structured DNA and compact chromatin. Recent …

In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …

INTRODUCTION The human body is a crowded place. This crowding is even more acute
when the regulation of cell growth and proliferation fails during the formation of a tumor …

Oncoproteins of the MYC family are major drivers of human tumorigenesis. Since a large
body of evidence indicates that MYC proteins are transcription factors, studying their function …

Oncogene activation disturbs cellular processes and accommodates a complex landscape
of changes in the genome that contribute to genomic instability, which accelerates mutation …

Replication stress is a complex phenomenon that has serious implications for genome
stability, cell survival and human disease. Generation of aberrant replication fork structures …

Replication fork reversal protects forks from breakage after poisoning of Topoisomerase 1.
We here investigated fork progression and chromosomal breakage in human cells in …

The frequent occurrence of transcription and DNA replication in cells results in many
encounters, and thus conflicts, between the transcription and replication machineries. These …

The remodelling of replication forks into four-way junctions following replication perturbation,
known as fork reversal, was hypothesized to promote DNA damage tolerance and repair …

RNA: DNA hybrid structures known as R loops were thought to be rare byproducts of
transcription. In the last decade, however, accumulating evidence has pointed to a new view …