Recombinant therapeutic proteins (RTPs) are important parts of biopharmaceuticals.
Chinese hamster ovary cells (CHO) have become the main cell hosts for the production of …

Immune recognition by T lymphocytes and natural killer (NK) cells is in large part dependent
on the identification of cell surface MHC molecules bearing peptides generated from either …

The conformational landscapes of peptide/human leucocyte antigen (pHLA) protein
complexes encompassing tumor neoantigens provide a rationale for target selection …

Chaperones Tapasin and TAP-binding protein related (TAPBPR) perform the important
functions of stabilizing nascent MHC-I molecules (chaperoning) and selecting high-affinity …

Highlights•MHC-I molecules exhibit allotype-dependent conformational flexibility, which is
critical for their function.•Peptide-deficient MHC-I adopt distinct groove conformations …

Human Tapasin (hTapasin) is the main chaperone of MHC-I molecules, enabling peptide
loading and antigen repertoire optimization across HLA allotypes. However, it is restricted to …

Class I major histocompatibility complex (MHC-I) proteins play a pivotal role in adaptive
immunity by displaying epitopic peptides to CD8+ T cells. The chaperones tapasin and …

Adaptive immune responses are triggered by antigenic peptides presented on major
histocompatibility complex class I (MHC I) at the surface of pathogen-infected or cancerous …

The secretory capacity of Chinese hamster ovary (CHO) cells remains a fundamental
bottleneck in the manufacturing of protein-based therapeutics. Unconventional biological …

Human Tapasin (hTapasin) is the main chaperone of MHC-I molecules, enabling peptide
loading and antigen repertoire optimization across HLA allotypes. However, it is restricted to …