The recent increase in organoid research has been met with great enthusiasm, as well as
expectation, from the scientific community and the public alike. There is no doubt that this …

Light-sheet fluorescence microscopy has transformed our ability to visualize and
quantitatively measure biological processes rapidly and over long time periods. In this …

Advances of analytical methods and emerging microfluidic tools have made it possible to
investigate biological processes in living organisms in detail and reach sensitivities sufficient …

Brain cancer remains the deadliest cancer. The blood–brain barrier (BBB) is impenetrable to
most drugs and is a complex 3D network of multiple cell types including endothelial cells …

We recently constructed a multicellular spheroid model of pancreatic tumor based on a triple
co-culture of cancer cells, fibroblasts and endothelial cells and characterized by the …

A major contributor to treatment failure in Chagas disease, caused by infection with the
protozoan parasite Trypanosoma cruzi, is that current treatment regimens do not address the …

The introduction of light sheet fluorescence microscopy (LSFM) has overcome the
challenges in conventional optical microscopy. Among the recent breakthroughs in …

In this study, a continuous cell-imaging system with subcellular resolution was developed by
integrating a microfluidic platform with lattice lightsheet microscopy (LLSM). To reduce …

The zebrafish has become a widely accepted model host for studies of infectious disease,
including fungal infections. The species is genetically tractable, and the larvae are …

Selective plane illumination microscopy can image biological samples at a high
spatiotemporal resolution. Complex sample preparation and system alignment normally limit …