Abstract The Infectious Diseases Society of America (IDSA) continues to view with concern
the lean pipeline for novel therapeutics to treat drug-resistant infections, especially those …

In apparent contrast to its invasive potential Staphylococcus aureus colonizes the anterior
nares of 20–80% of the human population. The relationship between host and microbe …

Staphylococcus aureus infection is a frequent cause of sepsis in humans, a disease
associated with high mortality and without specific intervention. When suspended in human …

BACKGROUND Novel therapeutic approaches are critically needed for Staphylococcus
aureus bloodstream infections (BSIs), particularly for methicillin-resistant S. aureus (MRSA) …

Staphylococcus aureus is a highly successful bacterial pathogen owing to its abundance of
cell surface and secreted virulence factors. It is estimated that 30% of the population is …

Staphylococcus aureus is a common human pathogen highly evolved as both a component
of the commensal flora and as a major cause of invasive infection. Severe respiratory …

Staphylococcus aureus is a facultative, Gram-positive coccus well known for its disease-
causing capabilities. In particular, methicillin and vancomycin resistant strains of S. aureus …

Gram-positive organisms with their thick envelope cannot be lysed by complement alone.
Nonetheless, antibody-binding on the surface can recruit complement and mark these …

Purpose Hospital-acquired bacterial pneumonia (HABP) is a critical concern in hospitals
with ventilator-associated bacterial pneumonia (VABP) remaining the most common …

The growing incidence of serious infections mediated by methicillin-resistant
Staphylococcus aureus (MRSA) strains poses a significant risk to public health. This risk is …