Regulation of microRNA function in animals

LFR Gebert, IJ MacRae - Nature reviews Molecular cell biology, 2019 - nature.com
Since their serendipitous discovery in nematodes, microRNAs (miRNAs) have emerged as
key regulators of biological processes in animals. These small RNAs form complex networks …

microRNA strand selection: Unwinding the rules

JC Medley, G Panzade… - Wiley Interdisciplinary …, 2021 - Wiley Online Library
Abstract microRNAs (miRNAs) play a central role in the regulation of gene expression by
targeting specific mRNAs for degradation or translational repression. Each miRNA is post …

The rise of regulatory RNA

KV Morris, JS Mattick - Nature Reviews Genetics, 2014 - nature.com
Discoveries over the past decade portend a paradigm shift in molecular biology. Evidence
suggests that RNA is not only functional as a messenger between DNA and protein but also …

Non-canonical features of microRNAs: paradigms emerging from cardiovascular disease

D Santovito, C Weber - Nature Reviews Cardiology, 2022 - nature.com
Research showing that microRNAs (miRNAs) are versatile regulators of gene expression
has instigated tremendous interest in cardiovascular research. The overwhelming majority of …

Nontemplated nucleotide additions distinguish the small RNA composition in cells from exosomes

D Koppers-Lalic, M Hackenberg, IV Bijnsdorp… - Cell reports, 2014 - cell.com
Functional biomolecules, including small noncoding RNAs (ncRNAs), are released and
transmitted between mammalian cells via extracellular vesicles (EVs), including endosome …

Circulating microRNAs: novel biomarkers and extracellular communicators in cardiovascular disease?

EE Creemers, AJ Tijsen, YM Pinto - Circulation research, 2012 - Am Heart Assoc
In the past few years, the crucial role of different micro-RNAs (miRNAs) in the cardiovascular
system has been widely recognized. Recently, it was discovered that extracellular miRNAs …

Evolution of microRNA diversity and regulation in animals

E Berezikov - Nature Reviews Genetics, 2011 - nature.com
In the past decade, microRNAs (miRNAs) have been uncovered as key regulators of gene
expression at the post-transcriptional level. The ancient origin of miRNAs, their dramatic …

Extracellular microRNA: a new source of biomarkers

A Etheridge, I Lee, L Hood, D Galas, K Wang - … Research/Fundamental and …, 2011 - Elsevier
MicroRNAs (miRNAs) are a recently discovered class of small, non-coding RNAs that
regulate protein levels post-transcriptionally. miRNAs play important regulatory roles in …

IsomiRs–the overlooked repertoire in the dynamic microRNAome

CT Neilsen, GJ Goodall, CP Bracken - Trends in genetics, 2012 - cell.com
The development of deep sequencing has enabled the identification of novel microRNAs
(miRNAs), leading to a growing appreciation for the fact that individual miRNAs can be …

Comprehensive profiling of circulating microRNA via small RNA sequencing of cDNA libraries reveals biomarker potential and limitations

Z Williams, IZ Ben-Dov, R Elias… - Proceedings of the …, 2013 - National Acad Sciences
We profiled microRNAs (miRNAs) in cell-free serum and plasma samples from human
volunteers using deep sequencing of barcoded small RNA cDNA libraries. By introducing …