Adenosine is an evolutionary ancient metabolic regulator linking energy state to physiologic
processes, including immunomodulation and cell proliferation. Tumors create an adenosine …

Simple Summary Tumor hypoxia remains a significant problem in the effective treatment of
most cancers. Tumor cells within hypoxic niches tend to be largely resistant to most …

Introduction Hypoxic tumors, unlike normal tissues, overexpress proteins involved in oxygen
sensing, metabolism, pH regulation, angiogenesis, immunological response, and other …

A series of adamantyl carboxamide derivatives containing sulfonate or sulfonamide moiety
were designed as multitargeted inhibitors of ectonucleotide pyrophosphatases …

Introduction Ectobucleotidases are a broad class of extracellular nucleotide and nucleoside
hydrolyzing enzymes. Since they play a crucial role in mediating purinergic cell signalling …

Herein, we describe the design, synthesis and biological evaluation of a series of novel non-
nucleotide sulfonylurea and sulfonylthiourea based small molecule inhibitors of h-ENPP1, h …

Herein, we describe the design, synthesis and biological evaluation of a series of novel non-
nucleotide sulfonylurea and sulfonylthiourea based small molecule inhibitors of h-ENPP1, h …