Sterol biosynthesis in Pneumocystis: unique steps that define unique targets
ES Kaneshiro - Drug resistance updates, 2002 - Elsevier
Pneumocystis lacks ergosterol, and several antimycotics that bind ergosterol in fungal
membranes or inhibit its synthesis are ineffective against Pneumocystis pneumonia. The …
membranes or inhibit its synthesis are ineffective against Pneumocystis pneumonia. The …
Comprehensive and definitive structural identities of Pneumocystis carinii sterols
JL Giner, H Zhao, DH Beach, EJ Parish… - Journal of lipid …, 2002 - ASBMB
Pneumocystis causes a type of pneumonia in immunodeficient mammals, such as AIDS
patients. Mammals cannot alkylate the C-24 position of the sterol side chain, nor can they …
patients. Mammals cannot alkylate the C-24 position of the sterol side chain, nor can they …
C27 to C32 sterols found in Pneumocystis, and opportunistic pathogen of immunocompromised mammals
ES Kaneshiro, MA Wyder - Lipids, 2000 - Springer
Pneumocystis carinii is the paradigm of opportunistic infections in immunocompromised
mammals. Prior to the acquired immunodeficiency syndrome (AIDS) pandemic and the use …
mammals. Prior to the acquired immunodeficiency syndrome (AIDS) pandemic and the use …
Sterols of Pneumocystis carinii hominisOrganisms Isolated from Human Lungs
ES Kaneshiro, Z Amit, J Chandra… - Clinical Diagnostic …, 1999 - Am Soc Microbiol
The opportunistic pathogen Pneumocystis carinii causes pneumonia (P. carinii pneumonia,
or PCP) in immunocompromised individuals such as AIDS patients. Rat-derived P. carinii …
or PCP) in immunocompromised individuals such as AIDS patients. Rat-derived P. carinii …
Sterol metabolism in the opportunistic pathogen Pneumocystis: Advances and new insights
ES Kaneshiro - Lipids, 2004 - Springer
Pneumocystis can transiently colonize healthy individuals without causing adverse
symptoms, and most people test positive for exposure to this organism early in life. However …
symptoms, and most people test positive for exposure to this organism early in life. However …
Sterol Composition of Pneumocystis jirovecii with Blocked 14α‐Demethylase Activity
JL GINER, H Zhao, Z Amit… - Journal of Eukaryotic …, 2004 - Wiley Online Library
Several drugs that interact with membrane sterols or inhibit their syntheses are effective in
clearing a number of fungal infections. The AIDS‐associated lung infection caused by …
clearing a number of fungal infections. The AIDS‐associated lung infection caused by …
EVIDENCE FOR METABOLISM OF SCAVENGED STEROLS BY THE P CARINII SAM: SMT: TRANSMETHYLATION OF DESMOSTEROL
DN WORSHAM - 2004 - rave.ohiolink.edu
Pneumocystis, an opportunistic fungal protist, causes a type of pneumonia in
immunocompromised individuals such as AIDS patients. Rat-derived P. carinii and human …
immunocompromised individuals such as AIDS patients. Rat-derived P. carinii and human …