Gene-environment interactions in schizophrenia: review of epidemiological findings and future directions

J Van Os, BPF Rutten, R Poulton - Schizophrenia bulletin, 2008 - academic.oup.com
Concern is building about high rates of schizophrenia in large cities, and among immigrants,
cannabis users, and traumatized individuals, some of which likely reflects the causal …

Catechol-o-methyltransferase, cognition, and psychosis: Val158Met and beyond

EM Tunbridge, PJ Harrison, DR Weinberger - Biological psychiatry, 2006 - Elsevier
This review summarizes our current understanding of catechol-o-methyltransferase (COMT)
and how it relates to brain function and schizophrenia. We begin by considering the COMT …

Evidence that onset of clinical psychosis is an outcome of progressively more persistent subclinical psychotic experiences: an 8-year cohort study

MDG Dominguez, M Wichers, R Lieb… - Schizophrenia …, 2011 - academic.oup.com
This study examined the hypothesis that developmental expression of psychometric risk in
the form of subclinical psychotic experiences in the general population is usually transitory …

The antisaccade task as a research tool in psychopathology: a critical review

SB Hutton, U Ettinger - Psychophysiology, 2006 - Wiley Online Library
The antisaccade task is a measure of volitional control of behavior sensitive to fronto‐striatal
dysfunction. Here we outline important issues concerning antisaccade methodology …

Schizotypal personality: neurodevelopmental and psychosocial trajectories

A Raine - Annu. Rev. Clin. Psychol., 2006 - annualreviews.org
Schizotypal personality research holds the promise of critically important insights into the
etiology and ultimate prevention of schizophrenia. This article provides a critical overview of …

[图书][B] Schizotypy and schizophrenia: The view from experimental psychopathology

MF Lenzenweger - 2011 - books.google.com
This compelling book argues that all people with schizophrenia share a personality
organization known as schizotypy. Presented is a novel framework for understanding …

The endophenotype concept in psychiatric genetics

J Flint, MR Munafò - Psychological medicine, 2007 - cambridge.org
The idea that some phenotypes bear a closer relationship to the biological processes that
give rise to psychiatric illness than diagnostic categories has attracted considerable interest …

Meta-analysis of the cognitive effects of the catechol-O-methyltransferase gene Val158/108Met polymorphism

JH Barnett, L Scoriels, MR Munafò - Biological psychiatry, 2008 - Elsevier
BACKGROUND: Cognitive endophenotypes may further our understanding of the genetic
basis of psychiatric disorders, and the catechol-O-methyltransferase (COMT) gene is a …

The molecular genetics of cognition: dopamine, COMT and BDNF

J Savitz, M Solms, R Ramesar - Genes, brain and behavior, 2006 - Wiley Online Library
The important contribution of genetic factors to the development of cognition and intelligence
is widely acknowledged, but identification of these genes has proven to be difficult. Given a …

Do patients with schizophrenia exhibit aberrant salience?

JP Roiser, KE Stephan, HEM Den Ouden… - Psychological …, 2009 - cambridge.org
BackgroundIt has been suggested that some psychotic symptoms reflect 'aberrant salience',
related to dysfunctional reward learning. To test this hypothesis we investigated whether …