Background Vascular complications are the leading cause of morbidity and mortality among
patients with type 1 and type 2 diabetes mellitus. These vascular abnormalities result of a …

Approximately 20% to 40% of patients with type 1 or type 2 diabetes mellitus develop
diabetic kidney disease. This is a clinical syndrome characterized by persistent albuminuria …

Context: Recent developments indicate that pathophysiological mechanisms leading to β-
cell damage, insulin resistance, and the vascular complications of diabetes include an …

The molecular signaling mechanisms between glomerular cell types during
initiation/progression of diabetic kidney disease (DKD) remain poorly understood. We …

Glomerular endothelial cell (GEnC) fenestrations are analogous to podocyte filtration slits,
but their important contribution to the glomerular filtration barrier has not received …

Endothelial dysfunction is a critical and initiating factor of the vascular complications of
diabetes. Inflammation plays an important role in endothelial dysfunction regulated by …

Chronic kidney disease (CKD) is a growing global health problem. CKD is typically
associated with a prothrombotic tendency in the early stages of the disease, whereas in its …

Diabetic kidney disease (DKD) is the leading cause of CKD and end-stage kidney disease
(ESKD) worldwide. Approximately 30-40% of people with diabetes develop this …

Background: The relationship between diabetic nephropathy, visceral adipose tissue (VAT),
and inflammation has been shown. The neutrophil-to-lymphocyte ratio (NLR) and platelet-to …

Renal microvascular disease associated with diabetes [Diabetic kidney disease-DKD] is the
leading cause of chronic kidney disease. In DKD, glomerular basement membrane …