The erector spinae plane (ESP) block is an emerging regional anesthetic technique with
significant potential for clinical benefit. Nevertheless, its exact mechanism (s) of action has …

Background Fascial plane blocks (FPBs) target the space between two fasciae, rather than
discrete peripheral nerves. Despite their popularity, their mechanisms of action remain …

Systemic administration of the local anaesthetic lidocaine is antinociceptive in both acute
and chronic pain states, especially in acute postoperative and chronic neuropathic pain …

Neuropathic pain, caused by a lesion or disease affecting the somatosensory system, affects
between 3 and 17% of the general population. The treatment of neuropathic pain is …

The highly disagreeable sensation of pain results from an extraordinarily complex and
interactive series of mechanisms integrated at all levels of the neuroaxis, from the periphery …

Postoperative pain continues to be inadequately managed. While opioids remain the
mainstay for postoperative analgesia, their use can be associated with adverse effects …

Nearly all amputees continue to feel their missing limb as if it still existed, and many
experience chronic phantom limb pain (PLP). What is the origin of these sensations? There …

BACKGROUND: Postoperative pain management remains a significant challenge after
abdominal surgery. OBJECTIVE: The aim of this meta-analysis was to evaluate the efficacy …

Postherpetic neuralgia (PHN) is a common and often devastatingly painful condition. It is
also one of the most extensively investigated of the neuropathic pains. Patients with PHN …

Several independent pathophysiological mechanisms in both the peripheral and central
nervous system are responsible for sensory symptoms as well as spontaneous and evoked …