The evolution of glucagon has seen the transition from an impurity in the preparation of
insulin to the development of glucagon receptor agonists for use in type 1 diabetes. In type 2 …

The peptide hormone glucagon, discovered in late 1922, is secreted from pancreatic alpha
cells and is an essential regulator of metabolic homeostasis. This review summarises …

Summary Growth differentiation factor 15 (GDF15) induces weight loss and increases insulin
action in obese rodents. Whether and how GDF15 improves insulin action without weight …

Chronic kidney disease (CKD) remains a major epidemiological, clinical, and biomedical
challenge. During CKD, renal tubular epithelial cells (TECs) present a persistent …

Glucagon is secreted from the pancreatic alpha cells upon hypoglycemia and stimulates
hepatic glucose production. Type 2 diabetes is associated with dysregulated glucagon …

Glucagon and insulin are the main regulators of blood glucose. While the actions of insulin
are extensively mapped, less is known about glucagon. Besides glucagon's role in glucose …

Plasma glucose is tightly regulated via the secretion of the two glucose-regulating hormones
insulin and glucagon. Situated next to the insulin-secreting β-cells, the α-cells produce and …

Whole-body glucose homeostasis is coordinated through secretion of glucagon and insulin
from pancreatic islets. When glucose is low, glucagon is released from α-cells to stimulate …

Abstract Type 2 alveolar epithelial (AT2) cells of the lung are fundamental in regulating
alveolar inflammation in response to injury. Impaired mitochondrial long-chain fatty acid β …

Discovered almost simultaneously with insulin, glucagon is a pleiotropic hormone with
metabolic action that goes far beyond its classical role to increase blood glucose. Albeit best …