The mechanistic target of rapamycin complex 1 (mTORC1) is a central regulator of metabolic
and nutrient cues that integrates environmental inputs into downstream signaling pathways …

Rapamycin is used frequently in both transplantation and oncology. Although historically
thought to have little diabetogenic effect, there is growing evidence of β-cell toxicity. This …

A major goal in diabetes research is to find ways to enhance the mass and function of insulin
secreting β-cells in the endocrine pancreas to prevent and/or delay the onset or even …

Pancreatic β cells differentiate during fetal life, but only postnatally acquire the capacity for
glucose-stimulated insulin secretion (GSIS). How this happens is not clear. In exploring what …

Pancreatic β cell dysfunction, ie, failure to provide insulin in concentrations sufficient to
control blood sugar, is central to the etiology of all types of diabetes. Current evidence …

Elucidating the mechanism underlying the poor proliferative capacity of adult pancreatic β-
cells is critical to regenerative therapeutic approaches for diabetes. Here, we show that the …

The human endocrine pancreas consists of multiple cell types and plays a critical role in
glucose homeostasis. Here, we apply mass cytometry technology to measure all major islet …

Accumulating evidence indicates that G protein-coupled receptor kinase 2 (GRK2) is a
versatile protein that acts as a signaling hub by modulating G protein-coupled receptor …

Cell division involves a series of ordered and controlled events that lead to cell proliferation.
Cell cycle progression implies not only demanding amounts of cell mass, protein, lipid, and …

The beta-cell identity gene, pancreatic duodenal homeobox 1 (Pdx1), plays critical roles in
many aspects of the life of beta-cells including differentiation, maturation, function, survival …