Inflammation after spinal cord injury: a review of the critical timeline of signaling cues and cellular infiltration
DJ Hellenbrand, CM Quinn, ZJ Piper… - Journal of …, 2021 - Springer
Traumatic spinal cord injury (SCI) is a devastating neurological condition that results in a
loss of motor and sensory function. Although extensive research to develop treatments for …
loss of motor and sensory function. Although extensive research to develop treatments for …
The multifaceted nature of IL-10: regulation, role in immunological homeostasis and its relevance to cancer, COVID-19 and post-COVID conditions
Interleukin-10 (IL-10) is a pleiotropic cytokine that has a fundamental role in modulating
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …
inflammation and in maintaining cell homeostasis. It primarily acts as an anti-inflammatory …
Cytokines in inflammatory disease
This review aims to briefly discuss a short list of a broad variety of inflammatory cytokines.
Numerous studies have implicated that inflammatory cytokines exert important effects with …
Numerous studies have implicated that inflammatory cytokines exert important effects with …
Biology and therapeutic potential of interleukin-10
M Saraiva, P Vieira, A O'garra - Journal of Experimental Medicine, 2019 - rupress.org
The cytokine IL-10 is a key anti-inflammatory mediator ensuring protection of a host from
over-exuberant responses to pathogens and microbiota, while playing important roles in …
over-exuberant responses to pathogens and microbiota, while playing important roles in …
IL-10 family cytokines IL-10 and IL-22: from basic science to clinical translation
W Ouyang, A O'Garra - Immunity, 2019 - cell.com
Cytokines are among the most important effector and messenger molecules in the immune
system. They profoundly participate in immune responses during infection and inflammation …
system. They profoundly participate in immune responses during infection and inflammation …
JAK inhibition as a therapeutic strategy for immune and inflammatory diseases
DM Schwartz, Y Kanno, A Villarino, M Ward… - Nature reviews Drug …, 2017 - nature.com
The discovery of cytokines as key drivers of immune-mediated diseases has spurred efforts
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …
to target their associated signalling pathways. Janus kinases (JAKs) are essential signalling …
Tumor-associated macrophage subsets: shaping polarization and targeting
Q Zhang, M Sioud - International journal of molecular sciences, 2023 - mdpi.com
The tumor microenvironment (TME) is a critical regulator of tumor growth, progression, and
metastasis. Among the innate immune cells recruited to the tumor site, macrophages are the …
metastasis. Among the innate immune cells recruited to the tumor site, macrophages are the …
The role of the anti-inflammatory cytokine interleukin-10 in tissue fibrosis
Significance: Fibrosis is the endpoint of chronic disease in multiple organs, including the
skin, heart, lungs, intestine, liver, and kidneys. Pathologic accumulation of fibrotic tissue …
skin, heart, lungs, intestine, liver, and kidneys. Pathologic accumulation of fibrotic tissue …
Bifidobacterium alters the gut microbiota and modulates the functional metabolism of T regulatory cells in the context of immune checkpoint blockade
Immune checkpoint-blocking antibodies that attenuate immune tolerance have been used to
effectively treat cancer, but they can also trigger severe immune-related adverse events …
effectively treat cancer, but they can also trigger severe immune-related adverse events …
Immune modulation by curcumin: The role of interleukin-10
Cytokines are small secreted proteins released by different types of cells with specific effects
on cellular signaling and communication via binding to their receptors on the cell surface. IL …
on cellular signaling and communication via binding to their receptors on the cell surface. IL …