Ewing sarcoma is the second most frequent bone tumour of childhood and adolescence that
can also arise in soft tissue. Ewing sarcoma is a highly aggressive cancer, with a survival of …

Importance Alveolar soft-part sarcoma (ASPS) is a rare, translocation-driven sarcoma of the
soft tissues. Alveolar soft-part sarcoma often affects young adults and is characterized by …

Background Alveolar soft part sarcoma (ASPS) is a rare soft-tissue sarcoma with a poor
prognosis and no established therapy. Recently, encouraging responses to immune …

Abstract The Zero Childhood Cancer Program is a precision medicine program to benefit
children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline …

Genomic studies of pediatric cancer have primarily focused on specific tumor types or high-
risk disease. Here, we used a three-platform sequencing approach, including whole …

PURPOSE Rhabdomyosarcoma is the most common soft tissue sarcoma of childhood.
Despite aggressive therapy, the 5-year survival rate for patients with metastatic or recurrent …

We conducted integrative somatic–germline analyses by deeply sequencing 864 cancer-
associated genes, complete genomes and transcriptomes for 300 mostly previously treated …

Alveolar rhabdomyosarcoma is a life-threatening myogenic cancer of children and
adolescent young adults, driven primarily by the chimeric transcription factor PAX3–FOXO1 …

To evaluate the potential of an integrated clinical test to detect diverse classes of somatic
and germline mutations relevant to pediatric oncology, we performed three-platform whole …

Core regulatory transcription factors (CR TFs) orchestrate the placement of super-enhancers
(SEs) to activate transcription of cell-identity specifying gene networks, and are critical in …