Can AlphaFold's breakthrough in protein structure help decode the fundamental principles of adaptive cellular immunity?
T cells are essential immune cells responsible for identifying and eliminating pathogens.
Through interactions between their T-cell antigen receptors (TCRs) and antigens presented …
Through interactions between their T-cell antigen receptors (TCRs) and antigens presented …
Revolutionizing peptide‐based drug discovery: Advances in the post‐AlphaFold era
Peptide‐based drugs offer high specificity, potency, and selectivity. However, their inherent
flexibility and differences in conformational preferences between their free and bound states …
flexibility and differences in conformational preferences between their free and bound states …
Accurate modeling of peptide-MHC structures with AlphaFold
V Mikhaylov, CA Brambley, GLJ Keller, AG Arbuiso… - Structure, 2024 - cell.com
Major histocompatibility complex (MHC) proteins present peptides on the cell surface for T
cell surveillance. Reliable in silico prediction of which peptides would be presented and …
cell surveillance. Reliable in silico prediction of which peptides would be presented and …
LightMHC: A Light Model for pMHC Structure Prediction with Graph Neural Networks
The peptide-major histocompatibility complex (pMHC) is a crucial protein in cell-mediated
immune recognition and response. Accurate structure prediction is potentially beneficial for …
immune recognition and response. Accurate structure prediction is potentially beneficial for …
GraphMHC: Neoantigen prediction model applying the graph neural network to molecular structure
Neoantigens are tumor-derived peptides and are biomarkers that can predict prognosis
related to immune checkpoint inhibition by estimating their binding to major …
related to immune checkpoint inhibition by estimating their binding to major …
Predicting protein stability changes under multiple amino acid substitutions using equivariant graph neural networks
S Boyer, S Money-Kyrle, O Bent - arXiv preprint arXiv:2305.19801, 2023 - arxiv.org
The accurate prediction of changes in protein stability under multiple amino acid
substitutions is essential for realising true in-silico protein re-design. To this purpose, we …
substitutions is essential for realising true in-silico protein re-design. To this purpose, we …