HIV-1 Tat and opioids act independently to limit antiretroviral brain concentrations and reduce blood–brain barrier integrity

CR Leibrand, JJ Paris, AM Jones, QN Masuda… - Journal of …, 2019 - Springer
Poor antiretroviral penetration may contribute to human immunodeficiency virus (HIV)
persistence within the brain and to neurocognitive deficits in opiate abusers. To investigate …

Self-emulsifying nano carriers for improved oral bioavailability of lipophilic drugs

J Ahmad, K Kohli, SR Mir, S Amin - Reviews in Advanced …, 2012 - ingentaconnect.com
The purpose of this review is to give an insight into the importance and potential of self-
emulsifying nano carriers or selfemulsifying drug delivery systems (SEDDS) for systemic …

Effect of magnetic nanoparticles of Fe3O4 and wogonin on the reversal of multidrug resistance in K562/A02 cell line

J Cheng, L Cheng, B Chen, G Xia, C Gao… - International Journal …, 2012 - Taylor & Francis
Background Multidrug resistance is the main obstacle to the efficiency of systemic
chemotherapy against hematologic malignancy. This study investigated the reversible effect …

Development of a polymeric micellar formulation for valspodar and assessment of its pharmacokinetics in rat

Z Binkhathlan, DA Hamdy, DR Brocks… - European Journal of …, 2010 - Elsevier
The aim of this study was to assess the potential of polymeric micelles to solubilize
valspodar and modify its pharmacokinetics following intravenous and oral administration in …

In vitro and in vivo evaluations of the P-glycoprotein-mediated efflux of dibenzoylhydrazines

K Miyata, Y Nakagawa, Y Kimura, K Ueda… - Toxicology and Applied …, 2016 - Elsevier
Abstract P-glycoprotein (P-gp) is a member of the ATP-binding cassette transporter family. It
actively transports a wide variety of compounds out of cells to protect humans from …

[HTML][HTML] A double blinded, placebo-controlled pilot study to examine reduction of CD34+/CD117+/CD133+ lymphoma progenitor cells and duration of remission …

D Ito, M Childress, N Mason, A Winter, T O'Brien… - …, 2015 - ncbi.nlm.nih.gov
We previously described a population of lymphoid progenitor cells (LPCs) in canine B-cell
lymphoma defined by retention of the early progenitor markers CD34 and CD117 and “slow …

The Rgg 2/3 Quorum Sensing System Contributes to the Pathogenesis of Streptococcus pyogenes

A Gogos - 2022 - search.proquest.com
This thesis seeks to characterize the physiological importance and molecular mechanism
underlying a quorum system in Streptococcus pyogenes. This bacterium is most commonly …

[HTML][HTML] Cremophor EL

Z Binkhathlan - erstress-inhibitor.com
Cremophor EL is a nonionic surfactant widely used in pharma-ceutical formulations.
Nonetheless, there are several reports on the influence of this excipient on the protein …

Characterization of the self assembly of methoxy poly (ethylene oxide)-block-poly (α-benzyl carboxylate-ε-caprolactone) for the solubilization and in vivo delivery of …

Z Binkhathlan, S Elhasi, DR Brocks… - Current Drug …, 2012 - ingentaconnect.com
The aim of this study was to characterize the nanostructures formed from assembly of poly
(ethylene oxide)-bpoly (α-benzyl carboxylate ε-caprolactone)(PEO-b-PBCL) in water …

Cremophor EL alters the plasma protein binding and pharmacokinetic profile of valspodar in rats

Z Binkhathlan - Drug Research, 2017 - thieme-connect.com
Cremophor EL is a nonionic surfactant widely used in pharmaceutical formulations.
Nonetheless, there are several reports on the influence of this excipient on the protein …