Organ fibrosis is a lethal outcome of autoimmune rheumatic diseases such as systemic
sclerosis. Myofibroblasts are scar-forming cells that are ultimately responsible for the …

The extracellular matrix (ECM) is a complex network of macromolecules surrounding cells
providing structural support and stability to tissues. The understanding of the ECM and the …

Idiopathic pulmonary fibrosis (IPF) is an aging-associated, progressive, and irreversible lung
disease of unknown etiology, elusive pathogenesis, and very limited therapeutic options …

The development of senescence in tissues of different organs and in the immune system are
usually investigated independently of each other although during ageing, senescence in …

Fibrosis is the excessive deposition of a stable extracellular matrix (ECM); fibrotic tissue is
composed principally of highly crosslinked type I collagen and highly contractile …

Oxidative stress has been linked to various disease states as well as physiological aging.
The lungs are uniquely exposed to a highly oxidizing environment and have evolved several …

Accumulating evidences demonstrate that long-term exposure to atmospheric fine particles
and air pollutants elevates the risk of chronic obstructive pulmonary disease (COPD) …

Cardiac fibrosis is associated with increased stiffness of the myocardial extracellular matrix
(ECM) in part mediated by increased cardiac fibroblast proliferation However, our …

Abstract The expression of Ccn1 (Cyr61) is essential for cardiovascular development during
embryogenesis, whereas in adulthood it is associated with inflammation, wound healing …

Interactions between the lung epithelium and the immune system involve a tight regulation
to prevent inappropriate reactions and have been connected to several pulmonary diseases …