Age-related changes in the central auditory system

L Ouda, O Profant, J Syka - Cell and tissue research, 2015 - Springer
Aging is accompanied by the deterioration of hearing that complicates our understanding of
speech, especially in noisy environments. This deficit is partially caused by the loss of hair …

Neuroimaging biomarkers of neurodegenerative diseases and dementia

SL Risacher, AJ Saykin - Seminars in neurology, 2013 - thieme-connect.com
Neurodegenerative disorders leading to dementia are common diseases that affect many
older and some young adults. Neuroimaging methods are important tools for assessing and …

Relationship between DTI metrics and cognitive function in Alzheimer's disease

CD Mayo, MA Garcia-Barrera, EL Mazerolle… - Frontiers in aging …, 2019 - frontiersin.org
Introduction: Alzheimer's disease (AD) is a neurodegenerative disorder with a clinical
presentation characterized by memory impairment and executive dysfunction. Our group …

[HTML][HTML] Deep neural network heatmaps capture Alzheimer's disease patterns reported in a large meta-analysis of neuroimaging studies

D Wang, N Honnorat, PT Fox, K Ritter, SB Eickhoff… - NeuroImage, 2023 - Elsevier
Deep neural networks currently provide the most advanced and accurate machine learning
models to distinguish between structural MRI scans of subjects with Alzheimer's disease and …

Free-water diffusion tensor imaging improves the accuracy and sensitivity of white matter analysis in Alzheimer's disease

M Bergamino, RR Walsh, AM Stokes - Scientific reports, 2021 - nature.com
Magnetic resonance imaging (MRI) based diffusion tensor imaging (DTI) can assess white
matter (WM) integrity through several metrics, such as fractional anisotropy (FA), axial/radial …

Neuroimaging and other biomarkers for Alzheimer's disease: the changing landscape of early detection

SL Risacher, AJ Saykin - Annual review of clinical psychology, 2013 - annualreviews.org
The goal of this review is to provide an overview of biomarkers for Alzheimer's disease (AD),
with emphasis on neuroimaging and cerebrospinal fluid (CSF) biomarkers. We first review …

Dementia induces correlated reductions in white matter integrity and cortical thickness: a multivariate neuroimaging study with sparse canonical correlation analysis

BB Avants, PA Cook, L Ungar, JC Gee, M Grossman - Neuroimage, 2010 - Elsevier
We use a new, unsupervised multivariate imaging and analysis strategy to identify related
patterns of reduced white matter integrity, measured with the fractional anisotropy (FA) …

Voxel-based meta-analysis of grey matter changes in Alzheimer's disease

WY Wang, JT Yu, Y Liu, RH Yin, HF Wang… - Translational …, 2015 - Springer
Background Voxel-based morphometry (VBM) using structural brain MRI has been widely
used for the assessment of impairment in Alzheimer's disease (AD), but previous studies in …

Correlations between microstructural alterations and severity of cognitive deficiency in Alzheimer's disease and mild cognitive impairment: a diffusional kurtosis …

NJ Gong, CS Wong, CC Chan, LM Leung… - Magnetic Resonance …, 2013 - Elsevier
OBJECT: Diffusional kurtosis imaging (DKI), a natural extension of diffusion tensor imaging
(DTI), can characterize non-Gaussian diffusion in the brain. We investigated the capability of …

Bilateral brain regions associated with naming in older adults

LK Obler, E Rykhlevskaia, D Schnyer… - Brain and …, 2010 - Elsevier
To determine structural brain correlates of naming abilities in older adults, we tested 24
individuals aged 56–79 on two confrontation-naming tests (the Boston Naming Test (BNT) …