[HTML][HTML] The physiological, biochemical, and molecular roles of zinc transporters in zinc homeostasis and metabolism

T Kambe, T Tsuji, A Hashimoto… - Physiological …, 2015 - journals.physiology.org
Zinc is involved in a variety of biological processes, as a structural, catalytic, and intracellular
and intercellular signaling component. Thus zinc homeostasis is tightly controlled at the …

Cellular zinc metabolism and zinc signaling: from biological functions to diseases and therapeutic targets

B Chen, P Yu, WN Chan, F Xie, Y Zhang… - … and Targeted Therapy, 2024 - nature.com
Zinc metabolism at the cellular level is critical for many biological processes in the body. A
key observation is the disruption of cellular homeostasis, often coinciding with disease …

The environment and male reproduction: The effect of cadmium exposure on reproductive function and its implication in fertility

C De Angelis, M Galdiero, C Pivonello, C Salzano… - Reproductive …, 2017 - Elsevier
Cadmium is an environmental pollutant known as endocrine disruptor. Testis is particularly
susceptible to cadmium, and testis injury occurs at high but even low levels of exposure …

The SLC39 family of zinc transporters

J Jeong, DJ Eide - Molecular aspects of medicine, 2013 - Elsevier
Zinc is a trace element nutrient that is essential for life. This mineral serves as a cofactor for
enzymes that are involved in critical biochemical processes and it plays many structural …

Heavy metal poisoning: the effects of cadmium on the kidney

N Johri, G Jacquillet, R Unwin - Biometals, 2010 - Springer
The heavy metal cadmium (Cd) is known to be a widespread environmental contaminant
and a potential toxin that may adversely affect human health. Exposure is largely via the …

Mammalian zinc transporters: nutritional and physiologic regulation

LA Lichten, RJ Cousins - Annual review of nutrition, 2009 - annualreviews.org
Research advances defining how zinc is transported into and out of cells and organelles
have increased exponentially within the past five years. Research has progressed through …

Cadmium-induced testicular injury

ER Siu, DD Mruk, CS Porto, CY Cheng - Toxicology and applied …, 2009 - Elsevier
Cadmium (Cd) is an environmental toxicant and an endocrine disruptor in humans and
rodents. Several organs (eg, kidney, liver) are affected by Cd and recent studies have …

Analysis and update of the human solute carrier (SLC) gene superfamily

L He, K Vasiliou, DW Nebert - Human genomics, 2009 - Springer
The solute-carrier gene (SLC) superfamily encodes membrane-bound transporters. The
SLC superfamily comprises 55 gene families having at least 362 putatively functional protein …

Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals

JM Moulis - Biometals, 2010 - Springer
The widespread occurrence of cadmium in the environment continues to pose a threat to
human health despite attempts at limiting its technological uses. The biologically significant …

The two-domain elevator-type mechanism of zinc-transporting ZIP proteins

A Wiuf, JH Steffen, ER Becares, C Grønberg… - Science …, 2022 - science.org
Zinc is essential for all organisms and yet detrimental at elevated levels. Hence,
homeostasis of this metal is tightly regulated. The Zrt/Irt-like proteins (ZIPs) represent the …